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U.S. Department of Health and Human Services


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Dextrose 5% in Lactated Ringer’s Injection

Detailed View: Safety Labeling Changes Approved By FDA Center for Drug Evaluation and Research (CDER) – February 2013

Summary View



  • The osmolarity of 5% Dextrose in Lactated Ringer’s Injection is 530 mOsmol/liter (calc). Administration of substantially hypertonic solutions may cause venous irritation, including phlebitis.
  • Do not connect flexible plastic containers in series in order to avoid air embolism due to possible residual air contained in the primary container.


  • Update to include class reactions