• Decrease font size
  • Return font size to normal
  • Increase font size
U.S. Department of Health and Human Services

Safety

  • Print
  • Share
  • E-mail

Ionamin (Phentermine Resin) Capsules

Detailed View: Safety Labeling Changes Approved By FDA Center for Drug Evaluation and Research (CDER) – December 2012

Summary View

 

ADVERSE REACTIONS

Drug Interactions
  • In a single-dose study comparing the exposures after oral administration of a combination capsule of 15 mg Phentermine and 92 mg Topiramate to the exposures after oral administration of a 15 mg Phentermine capsule or a 92 mg Topiramate capsule, there is no significant Topiramate exposure change in the presence of phentermine. However in the presence of Topiramate, phentermine Cmax and AUC increase 13% and 42%, respectively.