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Protonix (pantoprazole sodium) for injection
Detailed View: Safety Labeling Changes Approved By FDA Center for Drug Evaluation and Research (CDER)
- agranulocytosis, pancytopenia and taste disorders (ageusia, dyseusia)
5 WARNINGS AND PRECAUTIONS
5.9 Concomitant use of Protonix with Methotrexate
- Literature suggests that concomitant use of PPIs with methotrexate (primarily at high dose; see methotrexate prescribing information) may elevate and prolong...
- Case reports, published population pharmacokinetic studies, and retrospective analyses suggest that concomitant.....
- weight changes
- fatigue and malaise
- insomnia and somnolence
- information about the drug-drug interaction between pantoprazole and clopidogrel