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U.S. Department of Health and Human Services

Safety

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Lotrel (amlodipine besylate and benazepril hydrochloride) Capsules

Detailed View: Safety Labeling Changes Approved By FDA Center for Drug Evaluation and Research (CDER) – October 2011

 

Summary View

 

DRUG INTERACTIONS

Drug/Drug interactions
  • added: Simvastatin: Co-administration of multiple doses of 10 mg of amlodipine with 80 mg simvastatin resulted in a 77% increase in exposure to simvastatin compared to simvastatin alone. Limit the dose of simvastatin in patients on amlodipine to 20 mg daily.
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