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U.S. Department of Health and Human Services


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Wellbutrin XL (bupropion hydrochloride) Extended-Release Tablets and Aplenzin (bupropion hydrobromide) Extended-Release Tablets

Detailed View: Safety Labeling Changes Approved By FDA Center for Drug Evaluation and Research (CDER) – July 2011


Summary View


Drug Interactions
  • information regarding drug-drug interactions between bupropion and drugs that inhibit or induce CYP2B6, such as ritonavir or efavirenz
  • information about potential interactions between bupropion and drugs which require metabolic activation by CYP2D6 in order to be effective (e.g., tamoxifen)
Drug-Laboratory Test Interactions
  • False-positive urine immunoassay screening tests for amphetamines have been reported in patients taking bupropion. This is due to.....


  • added.......content re: false positive test results for amphetamines