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U.S. Department of Health and Human Services

Safety

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Wellbutrin (bupropion HCl) tablets

Detailed View: Safety Labeling Changes Approved By FDA Center for Drug Evaluation and Research (CDER) – May 2010

 

Summary View

 

PRECAUTIONS

Drug Interactions
  • Addition of pharmacokinetic information from a series of studies concerning drug interactions between bupropion and ritonavir and lopinavir/ritonavir.
  • Addition of ticlopidine and clopidogrel as examples of drugs that are substrates of or inhibitors/inducers of CYP2B6 and thus may interact with bupropion. Addition of statement that bupropion increases the Cmax and AUC of citalopram by 30% and 40%, respectively.

MEDICATION GUIDE

(Wellbutrin XL and SR only)

  • An update to the statement “Do not chew, divide, or crush tablets” to add “as this may lead to an increased risk of adverse effects, including seizures”.