• Decrease font size
  • Return font size to normal
  • Increase font size
U.S. Department of Health and Human Services

Regulatory Information

  • Print
  • Share
  • E-mail

USP Therapeutic Categories Model Guidelines

Therapeutic CategoryPharmacologic ClassFormulary Key Drug Types
AnalgesicsNon-opioid Analgesics 
Opioid AnalgesicsOpioid Analgesics, Long-acting
 Opioid Analgesics, Short-acting
AnestheticsLocal Anesthetics 
AntibacterialsAminoglycosides 
Beta-lactam, CephalosporinsCephalosporin Antibacterials, 1st Generation
 Cephalosporin Antibacterials, 2nd Generation
 Cephalosporin Antibacterials, 3rd Generation
 Cephalosporin Antibacterials, 4th Generation
Beta-lactam, PenicillinsAmino Derivative Penicillins
 Extended Spectrum Penicillins
 Natural Penicillins
 Penicillinase-resistant Penicillins
Beta-lactam, Other 
MacrolidesErythromycins
 Ketolides
 Macrolides (Non-erythromycins, Non-ketolides)
Quinolones 
Sulfonamides 
Tetracyclines 
Antibacterials, OtherAntifolate Antibacterials
 Glycopeptide Antibacterials
 Lincomycin Antibacterials
 Nitrofuran Antibacterials
 Oxazolidinone Antibacterials
 Miscellaneous Antibacterials
AnticonvulsantsCalcium Channel Modifying Agents 
Gamma-aminobutyric Acid (GABA) Augmenting Agents 
Glutamate Reducing Agents 
Sodium Channel Inhibitors 
Anticonvulsants, Other 
Antidementia AgentsCholinesterase Inhibitors 
Glutamate Pathway Modifiers 
Antidementia Agents, Other 
AntidepressantsMonoamine Oxidase Inhibitors 
Serotonin/Norepinephrine Reuptake Inhibitors  
Tricyclics 
Antidepressants, Other 
Antidotes, Deterrents, and Toxicologic AgentsAntidotes 
DeterrentsAlcohol Deterrents
 Smoking Cessation Agents
Toxicologic AgentsOpioid Antagonists
Antiemetics 5-Hydroxytryptamine 3 (5-HT3) Antagonists
 Neurokinin 1 (NK1) Receptor Antagonists
 Antiemetics, Other
Antifungals Allylamine Antifungals
 Azole Antifungals
 Echinocandin Antifungals
 Polyene Antifungals
 Antifungals (Other)
Antigout Agents Renal Tubular Blocking Agents
 Xanthine Oxidase Inhibitors
 Antigout Agents (Non-renal Tubular Blocking Agents and Non-xanthine Inhibitors)
Anti-inflammatory AgentsGlucocorticoids 
Nonsteroidal Anti-inflammatory Drugs 
Antimigraine AgentsAbortiveErgot Alkaloids
 Triptans
ProphylacticBeta-adrenergic Blocking Agents
 Antimigraine Agents, Prophylactic (Non–beta-adrenergic Blocking Agents)
Antimyasthenic AgentsParasympathomimetics 
AntimycobacterialsAntituberculars 
Antimycobacterials, Other 
AntineoplasticsAlkylating AgentsEthylenimines/
Methylmelamines
 Nitrogen Mustards
 Nitrosoureas
 Alkylating Agents, Other
Antiangiogenic Agents 
Antiestrogens/ModifiersEstrogen-nitrosoureas
 Selective Estrogen Receptor Modulators, 1st Generation
AntimetabolitesPurine Analogs and Related Inhibitors
 Antimetabolites, Other
Aromatase Inhibitors, 3rd Generation 
Molecular Target InhibitorsEpidermal Growth Factor Receptor Kinase Inhibitors
 Multitargeted Kinase Inhibitors, Bcr-Abl/c-kit Receptor Tyrosine Kinases
 Multitargeted Kinase Inhibitors, Vascular Endothelial Growth Factor Receptor Tyrosine Kinases
Monoclonal AntibodiesAnti-CD20 Antibodies
Retinoids 
Antineoplastics, Other 
AntiparasiticsAnthelmintics 
AntiprotozoalsAntimalarials
 Antiprotozoals (Non-antimalarials)
Pediculicides/
Scabicides
 
Antiparkinson Agents Anticholinergics
 Catechol O-methyltransferase (COMT) Inhibitors
 Dopamine Agonists, Ergot
 Dopamine Agonists, Nonergot
 Dopamine Precursors
 Monoamine Oxidase B (MAO-B) Inhibitors
 Antiparkinson Agents, Other
AntipsychoticsAtypicals 
Conventional 
Antispasticity Agents  
AntiviralsAnti-cytomegalovirus (CMV) Agents 
Antihepatitis Agents 
Antiherpetic Agents 
Anti-human Immunodeficiency Virus (HIV) Agents, Fusion Inhibitors 
Anti-HIV Agents, Non-nucleoside Reverse Transcriptase Inhibitors 
Anti-HIV Agents, Nucleoside and Nucleotide Reverse Transcriptase Inhibitors 
Anti-HIV Agents, Protease Inhibitors 
Anti-influenza Agents 
AnxiolyticsAntidepressants 
Anxiolytics, Other 
Bipolar Agents  
Blood Glucose RegulatorsAntidiabetic Agents
Alpha Glucosidase Inhibitors
 Amylinomimetics
 Biguanides
 Dipeptidyl Peptidase-4 (DPP-4) Inhibitors
 Incretin Mimetics
 Meglitinides
 Sulfonylureas
 Thiazolidinediones
Glycemic Agents 
InsulinsInsulin, Rapid-acting
 Insulin, Short-acting
 Insulin, Intermediate-acting
 Insulin, Long-acting
 Insulin Mixtures, Short-acting and Intermediate-acting
 Insulin Mixtures, Analogs
Blood Products/Modifiers/Volume ExpandersAnticoagulantsAnticoagulants, Oral
 Factor Xa Inhibitors, Indirect
 Low Molecular Weight Heparins
Blood Formation ProductsColony Stimulating Factors
 Erythropoietins
CoagulantsProtease Inhibitors
Platelet Aggregation InhibitorsAdenosine Diphosphate P2Y12 Inhibitors
 Cyclic Adenosine Monophosphate Reuptake Inhibitors
 Phosphodiesterase III/Adenosine Uptake Inhibitors
Cardiovascular AgentsAlpha-adrenergic Agonists 
Alpha-adrenergic Blocking Agents 
AntiarrhythmicsAntiarrhythmics - Classes IA, B, and C
 Antiarrhythmics - Class Ia/II/III/IV
 Antiarrhythmics - Class II
 Antiarrhythmics - Class II/III
 Antiarrhythmics - Class III
 Antiarrhythmics - Class IV
Beta-adrenergic Blocking AgentsAlpha-beta–adrenergic Blocking Agents
 Cardioselective Beta-adrenergic Blocking Agents
 Nonselective Beta-adrenergic Blocking Agents
Calcium Channel Blocking AgentsCalcium Channel Blocking Agents (Non-dihydropyridines)
 Dihydropyridines
DiureticsCarbonic Anhydrase Inhibitors
 Loop Diuretics
 Potassium-sparing Diuretics
 Thiazide Diuretics
DyslipidemicsBile Acid Sequestrants
 Cholesterol Absorption Inhibitors
 Fibrates
 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) Reductase Inhibitors
 Nicotinic Acid
 Omega-3 Fatty Acids
Renin-angiotensin-aldosterone System InhibitorsAldosterone Receptor Antagonists
 Angiotensin-converting Enzyme (ACE) Inhibitors
 Angiotensin II Receptor Antagonists
VasodilatorsVasodilators, Direct-acting Arterial
 Vasodilators, Direct-acting Arterial/Venous
 Vasodilators, Endothelin Receptor Antagonists
Cardiovascular Agents, Other 
Central Nervous System AgentsAmphetamines, ADHD 
Non-amphetamines, ADHD 
Non-amphetamines, Other 
Dental and Oral Agents  
Dermatological Agents Dermatological Acne Agents
 Dermatological Anti-inflammatory Agents
 Dermatological Antipruritic Agents
 Dermatological Calcineurin Inhibitors
 Dermatological Caustic Agents
 Dermatological Emollients
 Dermatological Genital Wart Agents
 Dermatological Mitotic Inhibitors
 Dermatological Non-melanoma Skin Cancer Agents
 Dermatological Photochemotherapy Agents
 Dermatological Psoriasis Agents
 Dermatological Wound Care Agents
Enzyme Replacements/Modifiers Anti-cystine Agents
 Fabry Disease Treatment
 Gaucher's Disease Treatment
 Glucosylceramide Synthase Inhibitors
 Hereditary Tyrosinemia Type 1 (HT-1) Treatment
 Homocystinuria Treatment
 Hunter Syndrome Treatment
 Mucopolysaccharidosis Disease Treatment
 Pancrelipase Replacement 
 Severe Combined Immunodeficiency Disease (SCID) Treatment
 Sucrase Enzyme Replacement 
 Urea Cycle Disorder Treatment
Gastrointestinal AgentsAntispasmodics, Gastrointestinal 
Histamine2 (H2) Blocking Agents 
Irritable Bowel Syndrome Agents 
Protectants 
Proton Pump Inhibitors 
Gastrointestinal Agents, Other 
Genitourinary AgentsAntispasmodics, Urinary 
Benign Prostatic Hypertrophy AgentsAlpha 1-adrenergic Blocking Agents
 5 Alpha-reductase Inhibitors
Phosphate Binders 
Genitourinary Agents, Other 
Hormonal Agents, Stimulant/ Replacement/ Modifying (Adrenal)Glucocorticoids/
Mineralocorticoids
Glucocorticoids-Systemic
 Glucocorticoids-Topical-Low Potency
 Glucocorticoids-Topical-Medium Potency
 Glucocorticoids-Topical-High Potency
 Glucocorticoids-Topical-Very High Potency
 Mineralocorticoids
Hormonal Agents, Stimulant/
Replacement/
Modifying (Pituitary)
 Gonadotropins
 Growth Hormone Analogs
 Insulin-like Growth Factor Analogs
 Vasopressin Analogs
Hormonal Agents, Stimulant/
Replacement/
Modifying (Prostaglandins)
  
Hormonal Agents, Stimulant/
Replacement/
Modifying (Sex Hormones/
Modifiers)
Anabolic Steroids
 
Androgens 
Estrogens 
Progestins 
Selective Estrogen Receptor Modifying Agents 
Hormonal Agents, Stimulant/
Replacement/
Modifying (Thyroid)
  
Hormonal Agents, Suppressant (Adrenal)  
Hormonal Agents, Suppressant (Parathyroid) Calcimimetics
Hormonal Agents, Suppressant (Pituitary) Dopamine Agonists
 Gonadotropin-releasing Hormone Analogs
 Growth Hormone Antagonists
 Somatostatin Analogs
Hormonal Agents, Suppressant (Sex Hormones/
Modifiers)
Antiandrogens
 
Hormonal Agents, Suppressant (Thyroid)Antithyroid Agents 
Immunological AgentsImmune StimulantsVaccines to Prevent Anthrax
 Vaccines to Prevent Diphtheria
 Vaccines to Prevent Haemophilus Type B
 Vaccines to Prevent Hepatitis A
 Vaccines to Prevent Hepatitis B
 Vaccines to Prevent Japanese Encephalitis
 Vaccines to Prevent Measles
 Vaccines to Prevent Meningococcal Disease
 Vaccines to Prevent Mumps
 Vaccines to Prevent Papillomavirus Disease
 Vaccines to Prevent Pertussis
 Vaccines to Prevent Poliovirus
 Vaccines to Prevent Rabies
 Vaccines to Prevent Rotavirus Disease
 Vaccines to Prevent Rubella
 Vaccines to Prevent Tetanus
 Vaccines to Prevent Typhoid
 Vaccines to Prevent Varicella
 Vaccines to Prevent Yellow Fever
 Vaccines to Prevent Zoster
Immune SuppressantsImmune Suppressants (Non-TNF Inhibitors)
 Tumor Necrosis Factor (TNF) Inhibitors
Immunizing Agents, PassiveImmunoglobulins
ImmunomodulatorsInterferons, Alfa
 Interferons, Beta
 Interferons, Gamma
 Immunomodulators, Other
Inflammatory Bowel Disease AgentsGlucocorticoids 
Salicylates 
Sulfonamides 
Metabolic Bone Disease Agents Bisphosphonates, Oral
 Bisphosphonates, Parenteral
 Calcium Regulating Hormones
 Parathyroid Hormone Analogs
 Vitamin D–related Agents/Metabolic Bone Disease Agents
Ophthalmic AgentsOphthalmic Anti-allergy Agents 
Ophthalmic Antiglaucoma AgentsAlpha-adrenergic Agonists, Ophthalmic
 Beta-adrenergic Blocking Agents, Ophthalmic
 Carbonic Anhydrase Inhibitors, Ophthalmic
 Cholinergic Agonists, Ophthalmic
Ophthalmic Anti-inflammatoriesGlucocorticoids, Ophthalmic
 Nonsteroidal Anti-inflammatory Drugs, Ophthalmic
Ophthalmic Prostaglandin and Prostamide Analogs 
Ophthalmic Agents, Other 
Otic Agents Otic Anti-inflammatories
  
Respiratory Tract AgentsAntihistaminesHistamine1 (H1) Blocking Agents, Mildly/Non-sedating
 H1 Blocking Agents, Sedating
Anti-inflammatories, Inhaled Corticosteroids 
AntileukotrienesReceptor Antagonists
 Synthesis Inhibitors
Bronchodilators, Anticholinergic 
Bronchodilators, Phosphodiesterase Inhibitors (Xanthines) 
Bronchodilators, Sympathomimetic 
Mast Cell Stabilizers 
Pulmonary Antihypertensives 
Respiratory Tract Agents, Other 
Sedatives/Hypnotics  
Skeletal Muscle Relaxants  
Therapeutic Nutrients/Minerals/
Electrolytes
Electrolytes/Minerals 
VitaminsPrenatal Vitamins