Prostate CancerTotal Number of SREs (039)
With 21-day window Without 21-day window
ZOMETAŽ ZOMETA 4 mg Placebo 4 mg Placebo
SRE (+HCM) 112 155 167 258
Pathologic fracture 34 54 46 84
Vertebral fracture 10 20 10 30
Nonvertebral fracture 25 38 36 54
Radiation to bone 65 85 90 130
Spinal cord compression 10 15 13 17
Change to antineoplastic therapy 13 17 13 17