Bisphosphonate Bone Metastases TrialsProportion of Patients With Any SRE§(12, 010)

Patients, %

Treatment N 3 mo 6 mo 9 mo 12 mo

Pamidronate Study 12

Pam 90 mg 198 10 21 24 28

Placebo 179 21 32 41 44

ZOMETA® Study 010

ZOMETA 4 mg 183 31 38 40 47

ZOMETA 8/4 mg 160 31 39 45 49

Pam 90 mg 167 25 40 45 49

42

§Intent-to treat.

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