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2. Bigby, M. et al. Adverse Reactions to Isotretinoin. The Journal of the American Academy of Dermatology 18, 543-552, 1988.
This report showed that by 1988 there were 104 adverse drug reaction reports in the USA from the period of october 1982 to June 1985. This represented the highest number of adverse reaction reports received by any agency for any prescription drug. It also states that 22% of Adverse drug reactions for Accutane relate to central nervous system disorders such as headache, depression, dizziness, personality disorder and pseudotumor cerebri.