Rationale for Combining FP with Salmeterol
Fluticasone propionate is an effective inhaled anti-inflammatory corticosteroid with clinical benefit in COPD.
Salmeterol is a long-acting b2-adrenoceptor agonist with demonstrated efficacy in COPD.
Each molecule influences a different aspect of COPD pathophysiology, so together they provide a broad therapeutic cover.
There is some evidence of interaction between these molecules which may be important in improving the overall efficacy of the combination.