Salmeterol Reduces Airway Obstruction in COPD
Airway
Obstruction
Inflammation
Structural Changes
Smooth muscle contraction
Increased cholinergic tone
Loss of elastic recoil
Increased Neutrophils, macrophages,
CD8+ lymphocytes.
Elevated IL-8, TNFa?
Protease/anti-protease imbalance
Alveolar destruction
Collagen deposition
Glandular hypertrophy
Airway fibrosis
Symptoms
? FEV1
Exacerbations
Salmeterol Positive Effect
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