Anti-Inflammatory Effects of ICS in COPD
Reference N Duration Treatment/Day Outcome
Balbi 8 6 w BDP 1500mcg ? BAL neutrophils, IL-8 et al., 2000 and MPO
Confalonieri 24 8 w BDP 1500mcg ? Sputum neutrophils et al., 1998
Llewellyn-Jones 17 8 w FP 1500mcg ? Sputum neutrophil et al., 1996 chemotactic activity
Thompson 30 6 w BDP 1000mcg Improvement in bronchial et al., 1992 cell counts and epithelial lining fluid proteins
Yildiz 18 8 w FP 1500mcg ? Sputum neutrophils et al., 2000
Hattotuwa 37 12 w FP 1000mcg ? Biopsy CD8+/CD4+ et al., 1999, 2000 Tcell ratio and mast cells
Verhoeven 20 24 w FP 1000mcg ? Biopsy CD8+ Tcells and et al., 1999 eosinophils
Keatings 13 2 w BUD 1600mcg No change in total and et al.,1996 differential cell counts or TNF?, ECP, EPO and MPO
Culpitt 13 4 w FP 1000mcg No change in sputum et al., 1999 neutrophils, IL-8 or SLPI
O’Brien 5 6 w BDP 400mcg No change in sputum et al., 2001 neutrophils