#3: Modified Factorial Design

• Four arm trial for 3 investigational agents (Drugs A, B, and C):

  • OBR + A + B
  • OBR + A + C
  • OBR + B + C
  • OBR + A + B + C

• Assumption is that OBR or OBR + single study drug alone is inferior

• N is 33% less than needed for 3 separate trials

• The same active arm is compared against 3 control arms

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