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For Consumers

Revised Adult HIV Treatment Guidelines are available

On January 10, 2011, the Department of Health and Human Services Panel on Antiretroviral Guidelines for Adults and Adolescents released updated Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents.

The updated guidelines can be viewed and downloaded from the Adult and Adolescent Guidelines section of AIDSinfo web site at http://aidsinfo.nih.gov/ContentFiles/AdultandAdolescentGL.pdf.

Key changes, summarized in the preface to the guidelines, entitled What's New in the Guidelines?, are highlighted in yellow throughout the guidelines document.  The changes affect the following sections:

Introduction

CD4 T-cell Count

Viral Load Testing

Drug-Resistance Testing

What to Start: Initial Combination Regimens for the Antiretroviral-Naïve Patient

Hepatitis B (HBV)/HIV Coinfection

Mycobacterium Tuberculosis Disease with HIV Coinfection

Adverse Effects of Antiretroviral Agents

The following sections and their relevant tables have also been updated:
• Coreceptor Tropism Assays
• Treatment Goals
• Initiating Antiretroviral Therapy in Treatment-Naïve Patients
• What Not to Use
• Virologic and Immunologic Failure (previously titled “Management of Patients with Antiretroviral Treatment Failure”)
• Regimen Simplification
• Exposure-Response Relationship and Therapeutic Drug Monitoring for Antiretroviral Agents
• Acute HIV Infection
• HIV and Illicit Drug Users (with new Table)
• HIV-2 Infection
• Drug Interactions (and Tables)
• Drug Characteristics Tables (Appendices)

Richard Klein
Office of Special Health Issues
Food and Drug Administration

Kimberly Struble
Division of Antiviral Drug Products
Food and Drug Administration

Page Last Updated: 08/21/2014
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