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U.S. Department of Health and Human Services

For Consumers

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FDA-Approved Diabetes Medicines


On this page, all insulins can be found, as well as diabetes drugs from 2002 to the present. 

All FDA-approved medicines used in the treatment of diabetes are either taken orally, injected, or inhaled, and can be found at Drugs@FDA

For Drug Labeling information, click on the hyperlinked brand name or go to DailyMed, The National Library of Medicine database of current drug information.


Brand Name

Generic Name

Approval Date

pioglitazone hydrochloride and metformin hydrochloride
August 2005
Apidrainsulin glulisineFebruary 2004
rosiglitazone maleate and metformin HCl)October 2002
Bydureonexenatide syntheticJanuary 2012
ByettaexenatideApril 2005
Duetactpioglitazone hydrochloride and glimepirideJanuary 2013
Humaloginsulin lisproJune 1996
Humalog 50/5050% insulin lispro protamine and 50% insulin lisproJune 1996
Humalog 75/2575% insulin lispro protamine and 25% insulin lisproDecember 1999
Humulin NNPH (N)October 1982
Humulin 70/3070% NPH and 30% regularApril 1989
Humulin R 100Uregular (R) InsulinOctober 1982
Humulin R 500Uregular (R) Insulin (5 times concentration)October 1982
sitagliptin/metformin HCl
March 2007
Janumet XRsitagliptin and metformin HCl extended-releaseFebruary 2012
sitagliptin phosphate
October 2006
Jentaduetolinagliptin plus metformin hydrochloride
February 2012
sitagliptin and simvastatin
October 2011
Kombiglyze XRsaxagliptin/metformin hydrochloride extended-releaseNovember 2010
Lantusinsulin glargineApril 2000
Levemirinsulin detemirJune 2005
LucentisranibizumabAugust 2012
Metaglipglipizide/metformin HClOctober 2002
Novolin NNPH (N)July 1991
Novolin Rregular (R)June 1991
Novolin 70/3070% NPH and 30% regularJune 1991
NovologInsulin aspartNovember 2001
Novolog 70/3070% insulin aspart protamine and 30% insulin aspartNovember 2001
July 2009
PrandiMetrepaglinide/metformin hydrochlorideJune 2008
SymlinpramlintideMarch 2005
May 2011
January 2010
colesevelam hydrochloride
January 2008