The GRAS Substances (SCOGS) Database allows access to opinions and conclusions from 115 SCOGS reports published between 1972-1980 on the safety of over 370 Generally Recognized As Safe (GRAS) food substances. The GRAS ingredient reviews were conducted by the Select Committee in response to a 1969 White House directive by President Richard M. Nixon.
- SCOGS-Report Number: 49*
- Type Of Conclusion: 1
- ID Code: 3615-56-3
- Year: 1974
- 21 CFR Section: 186.1839
The results of sorbose-feeding test with fasted rats showed no acute toxic effects for sorbose given excess of potential human dietary exposure. The metabolic products of sorbose metabolism in animals do not appear to include toxic substances and the chemical structure of sorbose does not suggest potential hazards. The results of the only study of the carcinogenicity of sorbose, involving parenteral administration in rats, have been judged by the investigator and reviewers to be negative.
Based on these considerations, and the fact that sorbose is permitted only as an ingredient of cotton fabrics used in dry food packaging, the Select Committee concludes that:
There is no evidence in the available information on sorbose that demonstrates, or suggests reasonable grounds to suspect, a hazard to the public when it is used at levels that are now current or that might reasonably be expected in future.
*Complete reports containing details of the safety studies that formed the basis of the opinions and conclusions and are available from the National Technical Information Service (NTIS), 5285 Port Royal Road, Springfield, VA 22161 (703) 605-6000.