Food

Select Committee on GRAS Substances (SCOGS) Opinion: Glycerophosphates

The GRAS Substances (SCOGS) Database allows access to opinions and conclusions from 115 SCOGS reports published between 1972-1980 on the safety of over 370 Generally Recognized As Safe (GRAS) food substances. The GRAS ingredient reviews were conducted by the Select Committee in response to a 1969 White House directive by President Richard M. Nixon.

Calcium, manganese, and potassium glycerophosphate, and calcium and magnesium glycerophosphate (packaging)

SCOGS Report Number: 74
NTIS Accession Number: PB265506*
Year of Report: 1976
GRAS SubstanceID Code

21 CFR Section

Calcium glycerophosphate27214-00-2184.1201
Manganese glycerophosphate1320-46-3 
Potassium glycerophosphate1319-70-6 
Calcium glycerophosphate (packaging)27214-00-2181.29
Magnesium glycerophosphate (packaging)927-20-8181.29

SCOGS Opinion:

The glycerophosphate salts that are considered to be GRAS could provide absorbable sources of glycerol, phosphate, and their respective cations. However, glycerophosphates are not now widely used in foods. The Select Committee believes that the level of consumer exposure is very low and that use under limitations as a nutrient or dietary supplement will nor present a hazard to the public. In previous evaluations of glycerol and certain phosphates no evidence was found of a hazard to the public from the hydrolysis products of the glycerophosphates.

In light of the information reviewed and reported herein, the Select Committee concludes that:

There is no evidence in the available information on calcium glycerophosphate, potassium glycerophosphate and manganese glycerophosphate that demonstrates or suggests reasonable grounds to suspect a hazard to the public when they are used as nutrient supplements or as they might reasonably be expected to be so used in the future.

There is no evidence in the available information on calcium glycerophosphate and magnesium glycerophosphate that demonstrates or suggests reasonable grounds to suspect a hazard to the public when they are used in food packaging materials as now practiced or as they might be expected to be used for such purposes in the future.


*Complete reports containing details of the safety studies that formed the basis of the opinions and conclusions and are available from the National Technical Information Service (NTIS), 5285 Port Royal Road, Springfield, VA 22161 (703) 605-6000.

Page Last Updated: 10/01/2015
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