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U.S. Department of Health and Human Services

Food

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Select Committee on GRAS Substances (SCOGS) Opinion: Adipic acid

The GRAS Substances (SCOGS) Database allows access to opinions and conclusions from 115 SCOGS reports published between 1972-1980 on the safety of over 370 Generally Recognized As Safe (GRAS) food substances. The GRAS ingredient reviews were conducted by the Select Committee in response to a 1969 White House directive by President Richard M. Nixon.

Adipic acid

  • SCOGS-Report Number: 80*
  • Type Of Conclusion: 1
  • ID Code: 124-04-9
  • Year: 1976
  • 21 CFR Section: 184.1009

SCOGS Opinion:

Investigations on animals and humans show that adipic acid is readily absorbed from the alimentary tract. Much of the absorbed compound is rapidly excreted in the urine but a substantial portion is oxidized to carbon dioxide. The intermediate products formed indicate that it is metabolized by the same route as the fatty acids.

The tolerance of animals to adipic acid is comparable to that of certain normal metabolites such as citric acid. Adipic acid caused no harmful effects in animals in long-term tests in which it was added to the diet in amounts up to at least 1 percent (500mg per kg body weight per day). This is over 500 times the daily per capita intake estimated from the poundage reported to be used in food in 1970. The available evidence suggests that the metabolism of adipic acid in man is comparable to that of laboratory animals.

In view of the foregoing, the Select Committee concludes that: There is no evidence in the available information on adipic acid that demonstrates , or suggests reasonable grounds to suspect, a hazard to the public when it is used at levels that are now current or that might reasonably be expected in the future.

*Complete reports containing details of the safety studies that formed the basis of the opinions and conclusions and are available from the National Technical Information Service (NTIS), 5285 Port Royal Road, Springfield, VA 22161 (703) 605-6000.