The GRAS Substances (SCOGS) Database allows access to opinions and conclusions from 115 SCOGS reports published between 1972-1980 on the safety of over 370 Generally Recognized As Safe (GRAS) food substances. The GRAS ingredient reviews were conducted by the Select Committee in response to a 1969 White House directive by President Richard M. Nixon.
- SCOGS-Report Number: 64*
- Type Of Conclusion: 1
- ID Code: 9000-29-7
- Year: 1975
- 21 CFR Section: There is no CFR citation.
The literature on the biological activity of gum guaiac indicates that it is a substance of very low acute toxicity. A number of short- and long-term feeding studies in experimental animals at levels orders of magnitude greater than those to which humans might be exposed indicate the abscence of chronic effects. Daily ingestion by human subjects for nearly four years resulted in no observable adverse effects.
The Select Committee has found no indication that gum guaiac is currently used as a food ingredient.
In the light of the foregoing, the Select Committee concludes that:
There is no evidence in the available information on gum guaiac that demonstrates, or suggests seasonable grounds to suspect, a hazard to the public if it is used as an antioxidant at levels compatible with current limitations.
*Complete reports containing details of the safety studies that formed the basis of the opinions and conclusions and are available from the National Technical Information Service (NTIS), 5285 Port Royal Road, Springfield, VA 22161 (703) 605-6000.