The GRAS Substances (SCOGS) Database allows access to opinions and conclusions from 115 SCOGS reports published between 1972-1980 on the safety of over 370 Generally Recognized As Safe (GRAS) food substances. The GRAS ingredient reviews were conducted by the Select Committee in response to a 1969 White House directive by President Richard M. Nixon.
- SCOGS-Report Number: 12*
- Type Of Conclusion: 2
- ID Code: 9000-28-6
- Year: 1973
- 21 CFR Section: 184.1333
There is no evidence that consumption of gum ghatti by man has has adverse effects when used at present levels. However, this presumption of lack of hazard is based primarily on the absence of evidence of human toxicity, rather than on substantive evidence supporting this conclusion. In view of the sparseness of toxicity data, the Select Committee attaches greater possible significance to the preliminary evidence indicating the maternal toxicity of gum ghatti at very high oral doses to pregnant rats and rabbits than it might otherwise accord these few data. It may be advisable, in due course, to conduct feeding studies in several animal species, including pregnant animals, at dosage levels that approximate and exceed the current estimated maximum daily human intake.
The Select Committee has weighed the foregoing and concludes that:
There is no evidence in available information on gum ghatti that demonstrates a hazard to the public when it is used at levels that are now current and in the manner now practiced.
*Complete reports containing details of the safety studies that formed the basis of the opinions and conclusions and are available from the National Technical Information Service (NTIS), 5285 Port Royal Road, Springfield, VA 22161 (703) 605-6000.