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Redbook 2000: VII Glossary: Acronyms and Definitions

April 2004

Toxicological Principles for the Safety Assessment of Food Ingredients
Redbook 2000
Chapter VII. Glossary: Acronyms and Definitions

Return to Redbook 2000 table of contents

This guidance represents the Food and Drug Administration's (FDA's) current thinking on this topic. It does not create or confer any rights for or on any person and does not operate to bind FDA or the public. You can use an alternative approach if the approach satisfies the requirements of the applicable statutes and regulations. If you want to discuss an alternative approach, contact the FDA staff responsible for implementing this guidance. If you cannot identify the appropriate FDA staff, call the appropriate number listed on the title page of this guidance.


Act"The Act", i.e., Federal Food, Drug, and Cosmetic Act
ABSchromosome aberration(s)
ADIacceptable daily intake
ANOVAanalysis of variance
B-cellsB lymphocytes
B/Tratio of B to T lymphocytes
CACCancer Assessment Committee
CASChemical Abstract Service
CCFACCodex Committee for Food Additives and Contaminants
CFRCode of Federal Regulations
CFSANCenter for Food Safety and Applied Nutrition
CHOChinese hamster ovary [cell(s)]
CMIcell mediated immunity
CSOconsumer safety officer
DNAdeoxyribonucleic acid
DTHdelayed type hypersensitivity
EAFUSEverything Added to Food in the United States (database)
ECVAMEuropean Centre for the Validation of Alternative Methods
EDIestimated daily intake
ELISAenzyme-linked immunosorbent assay
EPAEnvironmental Protection Agency (United States)
FAPfood additive petition
FASEBFederation of American Societies for Experimental Biology
FASPfood additive safety profile
FCSfood contact substance
FCNFood Contact (Substance) Notification
FDAFood and Drug Administration
GLPgood laboratory practices
GMPsgood manufacturing practices
GRASgenerally recognized as safe
HGPRThypoxanthineguanine phosphoribosyl transferase activity
HTDhighest treatment dose
IARCInternational Agency for Research on Cancer
ICHInternational Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use
JECFAJoint (FAO/WHO) Expert Committee on Food Additives
LOELlowest observed effect level
LSDleast significant difference (refers to statistical test)
MFOmixed function oxidase
MLL5178Y mouse lymphoma cell
MLAmouse lymphoma assay
MLRmixed lymphocyte response
MTDmaximum tolerated dose
OECDOrganization for Economic Cooperation and Development
OFASOffice of Food Additive Safety (CFSAN)
PAFAPriority-Based Assessment of Food Additives (database)
PALSperiarteriolar lymphocyte sheath
PB-PKphysiologically based pharmacokinetic model
PWMpokeweed mitogen
QAUQuality Assurance Unit
QRACQuantitative Risk Assessment Committee
QRAsquantitative risk assessments
RBCred blood cells
Redbook IToxicological Principles for the Safety Assessment of Direct Food Food Additives and Color Additives Used in Food (1982)
Redbook IIdraft Toxicological Principles for the Safety Assessment of Direct Food Food Additives and Color Additives Used in Food (1993)
Redbook 2000Toxicological Principles for the Safety Assessment of Food Ingredients (2000, additions and updates in 2001, 2003, 2004)
RIAradio immunoassay
RNAribonucleic acid
SARstructure activity relationship
SCEsister chromatid exchange
SHESyrian hamster embryo cell
SOPstandard operating procedure
SRBCsheep red blood cells
T-cellsT-lymphocytes, or thymus derived cells
TKthymidine kinase
UDSunscheduled DNA synthesis
WBCwhite blood cells
WBAwhole body autoradiography