Chemical Contaminants, Metals, Natural Toxins & Pesticides Guidance Documents & Regulations

Guidance documents contain nonbinding recommendations.

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Chemical Contaminants

• Acrylamide in Food:

  • Request for Comments and for Scientific Data and Information (August 26, 2009)
  • Request for Comments and for Scientific Data and Information; Extension of Comment Period (November 18, 2009)
  • FDA Action Plan for Acrylamide in Food (March 2004)
  • FDA Draft Action Plan for Acrylamide in Food - February 24, 2003 Update (March 12, 2003)
  • FDA Draft Action Plan for Acrylamide in Food (September 20, 2002)

• Dioxins & PCBs:

  • Guidance for Industry: Possible Dioxin/PCB Contamination of Drug and Biological Products (PDF - 7.7KB) (August 1999)

• Furan:

  • Regulatory Report: Acrylamide, Furan and the FDA (June 2007)
  • FDA Action Plan for Furan in Food (September 2005)

• Melamine:

  • "Dear Colleague" Letter to the United States Food Manufacturing Industry, Regarding Melamine (October 10, 2008)

• Radionuclides

  • Compliance Policy Guide: Guidance Levels for Radionuclides in Domestic and Imported Foods (July 29, 2004)
  • Supporting Document for Guidance Levels for Radionuclides in Domestic and Imported Foods (July 29, 2004)

• Action Levels for Poisonous or Deleterious Substances in Human Food and Animal Feed (2000)

 

Metals

• Arsenic: Bottled Water: Arsenic Small Entity Compliance Guide (April 2009)
• Disinfectants: Bottled Water: Residual Disinfectants and Disinfection Byproducts Small Entity Compliance Guide (May 2009)

• Lead:

  • Guidance for Industry: The Safety of Imported Traditional Pottery Intended for Use with Food and the Use of the Term “Lead Free” in the Labeling of Pottery; and Proper Identification of Ornamental and Decorative Ceramicware (November 2010)
  • 1991 Letter to Bureau of Alcohol, Tobacco and Firearms Regarding Lead in Wine (March 2007)
  • Lead in Candy Likely To Be Consumed Frequently by Small Children: Recommended Maximum Level and Enforcement Policy (November 2006)
    • Supporting Document for Recommended Maximum Level for Lead in Candy Likely To Be Consumed Frequently by Small Children (November 2006)
  • Letter to Manufacturers, Importers, and Distributors of Imported Candy and Candy Wrappers (June 13, 1995)
• Uranium: Bottled Water: Uranium Small Entity Compliance Guide (April 2009)

 

Natural Toxins

• Guidance for Industry and FDA: Advisory Levels for Deoxynivalenol (DON) in Finished Wheat Products for Human Consumption and Grains and Grain By-Products used for Animal Feed (June 2010)
• Guidance for Industry: Fumonisin Levels in Human Foods and Animal Feeds (November 9, 2001)
  • Background Paper in Support of Fumonisin Levels in Corn and Corn Products Intended for Human Consumption (November 9, 2001)
  • Background Paper in Support of Fumonisin Levels in Animal Feed: Executive Summary of this Scientific Support Document (November 9, 2001)
• Compliance Policy Guidance for FDA Staff: Apple Juice, Apple Juice Concentrates, and Apple Juice Products - Adulteration with Patulin (October 22, 2001)
  • Background Paper on Patulin in Apple Juice, Apple Juice Concentrates,and Apple Juice Products (September 2001)

 

Pesticides

• Pesticide Chemicals: Channels of Trade Policy for Commodities With Residues of Pesticide Chemicals, for Which Tolerances Have Been Revoked, Suspended, or Modified by the Environmental Protection Agency Pursuant to Dietary Risk Considerations (May 2005)
• Methyl Parathion: Channels of Trade Policy for Commodities with Methyl Parathion Residues (December 2000)
• Vinclozolin: Channels of Trade Policy for Commodities with Vinclozolin Residues (June 12, 2002)