Doxycycline and penicillin G procaine are antibiotics used to treat bacterial infections in many different parts of the body. They do not work for viral infections (for example, the common cold). Doxycycline and penicillin G procaine have been approved for all forms of anthrax. (inhalational, gastrointestinal, and cutaneous). In October 2001, FDA published a Federal Register notice clarifying that these drugs were approved for inhalational anthrax (post-exposure). Use of doxycycline in children under 8 presents special concerns because of possible tooth discoloration. Long-term use of intravenous doxycycline or penicillin G procaine presents safety concerns, and patients should be switched, when appropriate, to other antibiotics to complete a 60 day course of therapy for inhalational anthrax (post-exposure).
Public Health Emergency Home Preparation Instructions for Doxycycline (Posted 7/2/2008)
- Palatability Evaluations of Doxycycline Solid Dosage Tablets Ground and Mixed in Food or Drinks (Issued and posted 7/3/2002)
- Stability and Dose Uniformity Evaluations of Doxycycline Solid Dosage Tablets Ground and Mixed in Food or Drinks (Issued and posted 7/3/2002)
- Federal Register Notice on Doxycycline and Penicillin G Procaine Administration for Inhalational Anthrax (Post-Exposure). HTML or PDF
- List of Published Literature Relied on in Issuing the Federal Register Notice on Doxycycline and Penicillin G Procaine Administration for Inhalational Anthrax (Post—Exposure)
- FDA Encourages Drug Firms to Revise Doxycycline and Penicillin G Procaine Labeling with Information for Treating Inhalational Anthrax (Post-Exposure). Talk Paper.
- Doxycycline (Vibramycin, Monodox, Doryx, Doxy , Atridox, Periodox, Vibra-Tabs ): Use by Pregnant and Lactating Women
- Questions and Answers for Consumers on Doxycycline
- Questions and Answers for Consumers on Penicillin G Procaine
Related Links from FDA
Questions and Answers about Anthrax Prevention and Treatment from the Department of Health and Human Services.
Antibiotic Resistance. Disease-causing microbes that have become resistant to drug therapy are an increasing public health problem. Tuberculosis, gonorrhea, malaria, and childhood ear infections are just a few of the diseases that have become hard to treat with antibiotic drugs. Part of the problem is that bacteria and other microorganisms that cause infections are remarkably resilient and can develop ways to survive drugs meant to kill or weaken them. This antibiotic resistance, also known as antimicrobial resistance or drug resistance, is due largely to the increasing use of antibiotics.
Search the National Library of Medicine's database, MEDLINE, for references to articles from medical journals
Information on Anthrax from the National Library of Medicine's MEDLINEplus. Consumer Information including FAQ's, latest news, symptoms and diagnosis, treatment, and prevention.
Centers for Disease Control. Division of Bacterial and Mycotic Disease information
Anthrax Vaccine program. Department of Defense.
For more information about doxycycline and penicillin G procaine, please contact the Division of Drug Information at firstname.lastname@example.org or 1-888-INFOFDA (463-6332).