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U.S. Department of Health and Human Services

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Doxycycline and Penicillin G Procaine for Inhalational Anthrax (Post-Exposure)

Doxycycline and penicillin G procaine are antibiotics used to treat bacterial infections in many different parts of the body. They do not work for viral infections (for example, the common cold). Doxycycline and penicillin G procaine have been approved for all forms of anthrax. (inhalational, gastrointestinal, and cutaneous). In October 2001, FDA published a Federal Register notice clarifying that these drugs were approved for inhalational anthrax (post-exposure). Use of doxycycline in children under 8 presents special concerns because of possible tooth discoloration. Long-term use of intravenous doxycycline or penicillin G procaine presents safety concerns, and patients should be switched, when appropriate, to other antibiotics to complete a 60 day course of therapy for inhalational anthrax (post-exposure).

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Background Information

For more information about doxycycline and penicillin G procaine, please contact the Division of Drug Information at druginfo@fda.hhs.gov or 1-888-INFOFDA (463-6332).