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U.S. Department of Health and Human Services

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Dispensing Pharmacists and Health Care Provider Instructions

Instructions to identify the wrong fill volume in Carpuject pre-filled cartridges from Hospira, Inc. 

This alert applies to Carpuject  pre-filled cartridges manufactured by Hospira, Inc. for the following products:
 

Product Name

Strength

Presentation

Demerol (meperidine HCl) Injection, USP

25 mg/mL

1 mL in 2.5 mL Carpuject, Luer Lock

 

50 mg/mL

1 mL in 2.5 mL Carpuject, Luer Lock

 

75 mg/mL

1 mL in 2.5 mL Carpuject, Luer Lock

Diazepam Injection, USP

5 mg/mL

2 mL in 2.5 mL Carpuject, Luer Lock

Fentanyl Citrate Injection, USP

100 mcg Fentanyl/2 mL

2 mL in 2.5 mL Carpuject, Luer Lock

Heparin Lock Flush Solution, USP

10 USP heparin units/mL

1 mL in 2.5 mL Carpuject, Luer Lock

 

100 USP heparin units/mL

1 mL in 2.5 mL Carpuject, Luer Lock

 

100 USP heparin units/mL

3 mL in 5 mL Carpuject, Luer Lock

 

10 USP heparin units/mL

5 mL in 5 mL Carpuject, Luer Lock

 

100 USP heparin units/mL

5 mL in 5 mL Carpuject, Luer Lock

Heparin Sodium Injection, USP

5,000 USP heparin units/mL

1 mL in 2.5 mL Carpuject, Luer Lock

 

10,000 USP heparin units/mL

0.5 mL in 2.5 mL Carpuject, Luer Lock

HYDROmorphone HCl Injection, USP

1 mg/mL

1 mL in 2.5 mL Carpuject, Luer Lock

 

2 mg/mL

1 mL in 2.5 mL Carpuject, Luer Lock

 

4 mg/mL

1 mL in 2.5 mL Carpuject, Luer Lock

Ketorolac Tromethamine Injection, USP

30 mg/mL

1 mL in 2.5 mL Carpuject, Luer Lock

Labetalol Hydrochloride Injection, USP

20 mg/4 mL (5 mg/mL)

4 mL in 5 mL Carpuject, Luer Lock

Lorazepam Injection, USP

2 mg/mL

1 mL in 2.5 mL Carpuject, Luer Lock

Metoprolol Tartrate Injection, USP

1 mg/mL

5 mL in 5 mL Carpuject, Luer Lock

Midazolam Injection, USP

2 mg/2 mL (1 mg/mL), Preservative-Free

2 mL in 2.5 mL Cartridge, iSecure Version 2

 

2 mg/2 mL (1 mg/mL), Preservative-Free

2 mL in 2.5 mL Carpuject, Luer Lock

Morphine Sulfate Injection, USP

4 mg/mL

1 mL in 2.5 mL Carpuject, Luer Lock

 

8 mg/mL

1 mL in 2.5 mL Carpuject, Luer Lock

 

10 mg/mL

1 mL in 2.5 mL Carpuject, Luer Lock

 

15 mg/mL

1 mL in 2.5 mL Carpuject, Luer Lock

Naloxone Hydrochloride Injection, USP

0.4 mg/mL

1 mL in 2.5 mL Carpuject, Luer Lock

Ondansetron Injection, USP

2 mg/mL

2 mL in 2.5 mL Cartridge, iSecure Version 2

Sodium Chloride Injection, USP

0.90%

2 mL in 2.5 mL Carpuject, Luer Lock

 

0.90%

3 mL in 5 mL Carpuject, Luer Lock

 

0.90%

5 mL in 5 mL Carpuject, Luer Lock

Dispensing Pharmacists and Health Care Provider Instructions:

When dispensing any of the potentially affected Hospira Carpuject pre-filled cartridges, visually inspect and verify the fill volume of the Carpuject cartridge before dispensing and before placing the cartridge in the holder to administer the product.  Ensure that the actual fill volume matches the labeled fill volume by comparing the volume in the cartridge to the graduation markings displayed on the cartridge.  For all cartridge sizes, the volume in the prefilled cartridge should be less than the total volume that the Carpuject is capable of holding.

The correct volumes for the cartridges is as follows:

  • For any 1.5 mL capacity Carpuject pre-filled cartridge, the correct amount of fill volume based on the product information is 1 mL.
  • For any 2.5 mL capacity Carpuject pre-filled cartridge, the correct amount of fill volume based on the product information may be 0.5 mL, 1 mL, or 2 mL. 
  • For any 5 mL capacity Carpuject pre-filled cartridge, the correct fill volume may be 3 mL, 4 mL, or 5 mL.

Do not dispense or use any Carpuject pre-filled cartridge having the incorrect fill volume. 

Pharmacies should return products that appear to have the incorrect fill volume to Hospira.  Hospira has provided photographs of the potentially affected products to assist you with correct fill identification.