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U.S. Department of Health and Human Services

Drugs

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Current Drug Shortages E - K

 

The majority of information in this section is provided to FDA by manufacturers. Communication between FDA and the public is an essential component of preventing and mitigating drug shortages. To ensure that the information in this section is current, FDA appreciates all information and updates about shortages provided by manufacturers. We post information about shortages as soon as we receive it from the manufacturers.  To report information about shortages or supply issues, manufacturers can send updates to drugshortages@fda.hhs.gov.  Healthcare professionals and patients are also encouraged to notify us of shortages at drugshortages@fda.hhs.gov.

*Food and Drug Administration Safety and Innovation Act (FDASIA) of 2012

**Listed by Generic name or Active Ingredient**

A  B  C  D  [E– K]  L  M  N  O  P  Q  R  S  T  U  V  W  X  Y  Z

 

Echothiophate Iodide (Phospholine Iodide) Ophthalmic Kit (initial posting date 3/20/2014)

Company Product Availability and Estimated Shortage Duration Related Information Shortage Reason
(per New Legislation-FDASIA)*
Date Updated
Pfizer
Customer Service:
1-800-666-7248 
 
Phospholine Iodide 0.125%, 6.25 mg/5 mL (NDC 0046-1065-05)

Unavailable.  Estimated recovery June 2014

  Delay in shipping of the drug.

New

3/20/2014

 

Ephedrine Sulfate Injection (initial posting date 4/3/2014)

Company Product Availability and Estimated Shortage Duration Related Information Shortage Reason
(per New Legislation-FDASIA)*
Date Updated
Akorn Pharmaceuticals
Customer Service:
1-800-932-5676
 
1 mL Single Dose Ampule (NDC 17478-515-00) 

Available Mid-April 2014

 N/A Other

 

Sandoz Inc.
Customer Service:
1-800-525-8747 

50 mg/mL


1 ml fill in 2 ml Vial (NDC 66758-008-01)


1 ml fill in 2 ml Vial, 25x2ml (NDC 66758-008-02) 

Target supply availability in 2Q 2014 
 
  Revised 4/8/2014

 

Epinephrine Injection (Initial Posting Date) – 4/27/2012

Company Product Availability and Estimated Shortage Duration Related Information Shortage Reason
(per New Legislation-FDASIA)*
Date Updated
Hospira, Inc.
Customer Service:
1-877-946-7747
1:10,000; 10 mL Abboject-1 ½ “ needle(NDC 0409-4921-34)

Available

Please check with your wholesaler for available inventory.

Shortage per Manufacturer:
Manufacturing delays

Other

Revised 4/13/2014
1:10,000; 10 mL Abboject-3 ½ “ needle (NDC 0409-4901-18)

Next delivery June 2014
Estimated recovery
2Q 2014

Amphastar Pharmaceuticals, Inc./IMS
Customer Service:
1-800-423-4136

1:10,000, 10mL Luer-Jet Prefilled Syringe

 

NDC 76329-3316-1

(old NDC 0548-3316-00)
Available  Amphastar is experiencing a product shortage due to an increase in product demand caused by market supply issues Demand for increase for drug Reverified 3/10/2014
 

Epinephrine Inj. USP, 1mg/mL, 30mL vial, NDC 76329-9061-00
Available  

American Regent/Luitpold 1-800-645-1706

30 mL vial, package of 5 (NDC 00517-1130-05)

Unavailable

Estimate release end-December 2013.

American Regent is currently not releasing the preserved 30 mL vial.

Other Revised 12/9/2013

 

Epinephrine 1mg/mL (Preservative Free) (Initial posting-6/21/12)

Company Product Availability and Estimated Shortage Duration Related Information Shortage Reason
(per New Legislation-FDASIA)*
Date Updated
Hospira, Inc.
Customer Service:
1-877-946-7747
1 mg/mL, 1 mL ampule, preservative-free (contains sulfite), package of 25 (NDC 00409-7241-01)

Available

Available  Other

Reverified 4/13/2014

JHP Pharma
1-877-547-4548
Adrenalin (epinephrine injection, USP)
1 mg/mL, 1 mL vial, (contains sulfite) pack of 25 
(NDC 42023-122-25)
 
Available     Reverified 12/17/2013
American Regent/Luitpold
1-800-645-1706

1 mg/mL, 1 mL ampule, preservative free, sulfite-free,
package of 25 (NDC 00517-1071-25)

Unavailable  - Product on backorder and will be made available as it is released.
 

Shortage per Manufacturer: Manufacturing delay
 

 

Delay in shipping of the drug. Demand increase for the drug. Reverified 4/21/2014 

 

Erythrocin Lactobionate Lyophilized Powder for Injection (Initial Posting - 4/21/2014) New!

Company Product Availability and Estimated Shortage Duration Related Information Shortage Reason
(per New Legislation-FDASIA)*
Date Updated
Hospira, Inc.
Customer Service:
 1-877-946-7747
500 mg Add-Vantage Vial
(NDC 0409-6476-44)
 
Next delivery April;
Estimated recovery August
Shortage per Manufacturer:  Manufacturing delay.
Please check with your wholesaler for available inventory.
Other  

 

Ethiodol (Ethiodized Oil) Ampules

Company Product Availability and Estimated Shortage Duration Related Information Shortage Reason
(per New Legislation-FDASIA)*
Date Updated
Guerbet LLC
Customer Service
(1-877-729-6679)
LIPIODOL ULTRA-FLUIDE, 48% Iodine w/vol (i.e. 480 mg Iodine/mL) (ethyl esters of iodized fatty acids of poppy seed oil) injection, 10 mL  (NDC 67684-1901-0)  Guerbet has acquired the Ethiodol NDA from Nycomed US Inc. effective May 7, 2010 and is working with FDA to resume manufacturing of Ethiodol in the near future to ensure continued availability for the US patients.

During this interim period, Guerbet, in conjunction with the FDA, is initiating a temporary importation of LIPIODOL ULTRA-FLUIDE, ethyl esters of iodized fatty acids of poppy seed oil, to the United States market.

See Dear Healthcare Professional Letter (PDF - 789KB) for additional information. (Letter updated 7/1/2013)
 

Shortage per Manufacturer:
Product has been discontinued by Nycomed US Inc. 

Discontinuation of the manufacture of the drug. Reverified 4/10/2014

 

 Fentanyl Citrate (Sublimaze) Injection

Company Product Availability and Estimated Shortage Duration Related Information Shortage Reason
(per New Legislation-FDASIA)*
Date Updated
Hospira, Inc.
Customer Service:
1-877-946-7747
0.05 mg/mL; 2 mL Carpuject
(NDC 0409-1276-32)

Next delivery late April 2014. 
Estimated recovery 2Q 2014

Carpuject orders (NDC 0409-1276-32) must be ordered through the wholesaler; check with your wholesaler regarding product allocation. It is recommended that the user institute fentanyl sparing strategies.

Shortage per Manufacturer:
Manufacturing delay/Available 

Other

Reverified
4/13/2014

0.05 mg/mL; 2 mL amp
(NDC 0409-9093-32)

Available

0.05 mg/mL; 5 mL amp
(NDC 0409-9093-35)

Available

0.05 mg/mL; 20 mL amp
(NDC 0409-9093-38)

Available

0.05 mg/mL; 2 mL vial
(NDC 0409-9094-22)

Next delivery April 2014 
Estimated recovery 2Q 2014

0.05 mg/mL; 5 mL vial
(NDC 0409-9094-25)

Available

0.05 mg/mL; 10 mL vial
(NDC 0409-9094-28)

Available

0.05 mg/mL; 20 mL vial
(NDC 0409-9094-31)

Available

0.05 mg/mL; 50 mL vial
(NDC 0409-9094-61)

Next delivery
May 2014
Estimated recovery 2Q 2014

West-Ward Pharmaceuticals
Customer Service:
1-800-631-2174
 

50 mcg/mL

2 mL ampul
(NDC 0641-6024-10)

West-Ward has quantities available for all presentations.
 

 

West-Ward has continued to accelerate production on all codes. 
 

 

 

Additional lots of all presentations are scheduled for manufacturing with anticipated availability in the April – May 2014 timeframe.
 

 

Product will be made available as it is released.

 

Demand increase for the drug.

Revised 3/30/2014

50 mcg/mL

5 mL ampul

(NDC 0641-6025-10)

50 mcg/mL

20 mL ampul

(NDC 0641-6026-05)

50 mcg/mL

2 mL vial

(NDC 0641-6027-25)

50 mcg/mL

5 mL vial

(NDC 0641-6028-25)

50 mcg/mL

20 mL vial

(NDC 0641-6029-25)

50 mcg/mL

 50 mL vial

(NDC 0641-6030-01)

Akorn Pharmaceuticals
1-800-932-5676
2 mL ampule; 10 pack
(NDC 17478-0030-02)
Readily
Available

 

Other

Reverified 4/16/2014

2 mL ampule; 25 pack
(NDC 17478-0030-25)

Readily
Available
5 mL ampule 25 pack (NDC 17478-0030-55) Readily
Available
5 mL ampule 10pack (NDC 17478-0030-05) Readily
Available
20 mL ampule
(NDC 17478-0030-20)
Readily
Available

  

Heparin Sodium Injection (Initial Posting - 7/5/2012)  

Company Product Availability and Estimated Shortage Duration Related Information Shortage Reason
(per New Legislation-FDASIA)*
Date Updated

Hospira Inc.
Customer Service:
1-877-946-7747

 

Heparin sodium 1000 U/mL; 1mL in 2mL Vial (NDC 0409-2720-01)

Available

Please check with your wholesaler for available inventory.
Shortage per Manufacturer:
Manufacturing delay; Available
 

Other

Reverified 4/13/2014

Heparin sodium 5000 U/0.5mL; 2mL Carpuject (NDC 0409-1316-32)

Available

Heparin sodium 1000 U/mL; 10mL multi-dose Vial (NDC 0409-2720-02)

Available

Heparin sodium 1000 U/mL; 30mL multi-dose Vial (NDC 0409-2720-03)

Available

Heparin sodium 5000 U/mL; 1mL in 2mL Vial (NDC 0409-2723-01)

Next delivery April 2014.
Estimated recovery 2Q 2014 

Heparin sodium 2 U/mL in 0.9% sodium chloride; 500 mL container
(NDC 0409-7620-03)

Available
 

Heparin sodium 50 U/mL in 0.45% sodium chloride; 250 mL container
(NDC 0409-7651-62)

Available

 
Heparin sodium 10000 U/mL; 1mL in 2mL Vial (NDC 0409-2721-01) Available   

Heparin sodium 50 U/mL in 0.45% sodium chloride; 500 mL container
(NDC 0409-7651-03)

Available

Heparin sodium 100 U/mL in 0.45% sodium chloride; 250 mL container (NDC 0409-7650-62)

Available

Heparin sodium 100 U/mL in 5% dextrose; 250 mL container
(NDC 0409-7793-62)

Available

Heparin sodium 50 U/mL in 5% dextrose; 250 mL container
(NDC 0409-7794-62)

Available

Heparin sodium 40 U/mL in 5% dextrose; 500 mL container
(NDC 0409-7760-03)

Next delivery and estimated recovery 2015

Heparin sodium 50 U/mL in 5% dextrose; 500 mL container
(NDC 0409-7761-03)
Next delivery and estimated recovery 2015

Pfizer
Customer Service:
Pfizer Injectables
1-800-533-4535

Heparin 5,000 units/mL 1mL Vial. (Not for lock flush) 25’s. NDC 0069-0059-03

Unavailable

Next batch expected 4/28/14 - full recovery estimated June 2014

Demand increase for the drug 

Revised
4/11/2014

B. Braun Medical Inc.
Customer Support
1-800-227-2862

Heparin Sodium (40 U/mL)/ 5% Dextrose in 500 mL flexible plastic container P5671 (NDC 0264-9567-10)

Not available.
Product availability in 2 months.

Intermittent supply.
Shortage per manufacturing disruption

Demand increase for the drug.

Unable to verify as of
10/25/2013

Heparin Sodium (50 U/mL)/5% Dextrose in 500 mL flexible plastic container P5771 (NDC 0264-9577-10)

Not available.
Product availability in 2 months.

Heparin Sodium (100 U/mL)/5% Dextrose in 250 mL flexible plastic container P5872 (NDC 0264-9587-20)

Not available.
Product availability in 2 months.

Baxter Healthcare Customer Service:
1-888-229-0001

1000 USP Heparin Units and 0.9% Sodium Chloride Injection in 500 mL (NDC 0338-0431-03)
 

Baxter continues to release product and anticipates supplies to recover by May 2014

 

Demand increase for the drug.

Reverified   3/17/2014

2000 USP Heparin Units and 0.9% Sodium Chloride Injection in 1000 mL (NDC 0338-0433-04)

Available

Sagent Pharmaceuticals
1-866-625-1618

Heparin sodium inj 1,000 units/ml 1 ml vial
(NDC 25021-400-01)

Allocation

 

Demand increase for the drug

 


 




 

Reverified 4/14/2014
 


 



 


 

Heparin sodium inj 1,000 units/ml 10ml vial
(NDC 25021-400-10)

Available

Heparin sodium inj 1,000 units/ml 30 ml vial
(NDC 25021-400-30)

Available
 

 

Heparin sodium inj 1,000 units/ml 2ml preservative free vial
(NDC 25021-401-02)

Available
 

 

Heparin sodium inj 5,000 units/ml 1ml vial
(NDC 25021-402-01)

Allocation

 

Heparin sodium inj 5,000 units/ml 10ml vial
(NDC 25021-402-10)

Available

Heparin sodium inj 10,000 units/ml 1 ml vial
(NDC 25021-403-01)

Available
 

 

Heparin sodium inj 10,000 units/ml 4ml vial
(NDC 25021-403-04)

Available
 

Heparin sodium inj 20,000 units/ml 1ml vial
(NDC 25021-404-01)

Available 

 

Fresenius Kabi, USA
(Formerly APP Pharmaceuticals, LLC)
1-888-386-1300
 

2,000 USP/ 2 mL SDV (NDC 63323-276-02)

Available.  Check wholesalers for inventory.

Check wholesalers for inventory.

 

Shortage per Manufacturer: Manufacturing Delay

 

 

 

Other 

 

 

 

Revised 4/8/2014

 

 

 

 

 

1,000 USP/ 1 mL MDV (NDC 63323-540-01)

Available.  Check wholesalers for inventory.

10,000 USP / 10 mL MDV (NDC 63323-540-11)

Available.  Check wholesalers for inventory.

30,000 USP/ 30 mL  MDV (NDC 63323-540-31)

Available.  Check wholesalers for inventory.

5,000 USP / 0.5 mL SDV PF (NDC 63323-543-02)

Backordered.  Next release anticipated April 2014.
Check wholesalers for inventory.
 

5,000 USP/ 1 mL MDV (NDC 63323-262-01)

Available.
Check wholesalers for inventory.
 

50,000 USP/ 10 mL MDV (NDC 63323-047-10)

Available. Check wholesalers for inventory.

10,000 USP/ 1 mL MDV (NDC 63323-542-01)

Available. Check wholesalers for inventory.

50,000 USP/ 5 mL MDV (NDC 63323-542-07)

Available.  Check wholesalers for inventory.

40,000 USP / 4 mL MDV (NDC 63323-459-09)

Available.  Check wholesalers for inventory.

20,000 USP/ 1 mL  MDV (NDC 63323-915-01)

8 month dating available by request. Next release anticipated June 2014.
 

West-Ward Pharmaceuticals
Customer Service:
1-800-631-2174

1,000 units/mL, 1 mL vial (NDC 0641-0391-12)

West-Ward currently has inventory available for all presentations.

West-Ward has increased production and will have product available as it is released.
 

Demand increase for the drug.

Reverified 3/30/2014
 

5,000 units/mL, 1 mL vial (NDC 0641-0400-12)

10,000 units/mL, 1 mL vial (NDC 0641-0410-12)

1,000 units/mL, 30 mL vial (NDC 0641-2450-55)

5,000 units/mL, 10 mL vial (NDC 0641-2460-55)

 

Intravenous Fat Emulsion

For detailed clinical recommendations to use during this shortage, please see information posted by the American Society of Parenteral and Enteral Nutrition: http://www.nutritioncare.org/Professional_Resources/Information_to_Use_in_the_Event_of_an_Intravenous_Fat_Emulsion_Shortage/

disclaimer icon

Company Product Availability and Estimated Shortage Duration Related Information Shortage Reason
(per New Legislation-FDASIA)*
Date Updated
Hospira Inc. Customer Service:
1-877-946-7747
10%; 250 mL (NDC 0409-9790-02) Hospira continues to investigate manufacturing process improvements. Shortage per Manufacturer:
Quality improvement activities
 
Requirements related to complying with good manufacturing practices

Reverified 4/13/2014

10%; 500 mL (NDC 0409-9790-03)
20%; 250 mL (NDC 0409-9791-02)
20%; 500 mL (NDC 0409-9791-03)
30%; 500 mL (NDC 0409-6892-03)

Baxter (Intralipid Emulsion)
Customer Service:
(1-888-229-0001)
 

Intralipid 20% Emulsion, 100 mL (NDC 00338-0519-48)

 

 

Available

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Demand increase for the drug

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Revised 3/17/2014

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Intralipid 20% Emulsion, 250 mL (NDC 00338-0519-02)

 

 

Available

 

Intralipid 20% Emulsion, 500 mL (NDC 00338-0519-03)

Available

 

Intralipid 20% Emulsion, 1000 mL (NDC 00338-0519-04)

Available

Baxter Healthcare Corporation and Fresenius Kabi AB in conjunction with FDA has initiated temporary importation of the United Kingdom Intralipid 20% Intravenous Fat Emulsion into the US market to address this shortage. Please see the Dear Healthcare Professional Letter (PDF - 2.3MB) for additional product and supply information.

All orders must be made directly with Baxter's Center for Service by calling 1-888-229-0001

United Kingdom Intralipid 20% Emulsion in Biofine container:

100 mL (NDC 00338-0519-10)
250 mL (NDC 00338-0519-11)
500 mL (NDC 00338-0519-12)

Baxter has the United Kingdom Intralipid 20% emulsions in Biofine container for temporary importation with product available. The 100 and 250 mL products are  available 500 mL product is not available
Intralipid 30% Emulsion, 500 mL (NDC 00338-0520-03)

Available

 

 

 

Ketorolac Tromethamine Injection

Company Product Availability and Estimated Shortage Duration Related Information Shortage Reason
(per New Legislation-FDASIA)*
Date Updated

Bedford Customer Service
1-800-562-4797 

15 mg/mL 1 mL vial, 10 count (NDC 55390-0480-01)

Unavailable


 
Shortage per Manufacturer: Pending manufacturing change or addition.
Availability of products is updated on the Bedford Laboratories website.
 
Other

Reverified 4/21/2014 

 
30 mg/mL 1 mL vial, 10 count (NDC 55390-0481-01)
60 mg Inj SDV 2 mL (NDC 55390-481-02)
30 mg/mL 10 mL vial, 10 count (NDC 55390-0481-10)
American Regent/Luitpold
1-800-645-1706
15 mg/mL 1 mL vial, 25 count (NDC 00517-0601-25) Unavailable - No product available for release. No plan to manufacture. American Regent/Luitpold has discontinued manufacturing Ketorolac Tromethamine Injection, USP Discontinuation of the manufacture of the drug.

Reverified 4/21/2014

30 mg/mL 1 mL vial, 25 count (NDC 00517-0801-25)
30 mg/mL 2 mL vial for intramuscular use, 25 count (NDC 00517-0902-25)
Wockhardt
Customer Service:
1-800-346-6854

30 mg/mL 1 mL vial, 10 count (NDC 64679-0758-04)

No estimated release date available.
 
 
 
 
 
 
 
Requirements related to complying with good manufacturing practices
 

Reverified 4/8/2014

30 mg/mL 1 mL vial, 25 count (NDC 64679-0758-01)
30 mg/mL 2 mL vial, 10 count (NDC 64679-0758-06)
30 mg/mL 2 mL vial, 25 count (NDC 64679-0758-02)
15 mg/mL 1 mL vial, 10 count (NDC 64679-0757-02)
15 mg/mL 1 mL vial, 25 count (NDC 64679-0757-01)

Fresenius Kabi, USA
(Formerly APP Pharmaceuticals, LLC)
1-888-386-1300

15 mg/mL 1 mL vial, 25 count (NDC 63323-0161-01) Available.  Check wholesaler inventory.

Check wholesalers for inventory.

Demand increase for the drug.  Reverified 4/8/2014
30 mg/mL 1 mL vial, 25 count (NDC 63323-0162-01) Available.  Check wholesaler inventory.
30 mg/mL 2 mL vial for intramuscular injection, 25 count (NDC 63323-0162-02) Available.  Check wholesaler inventory.

Hospira, Inc.
Customer Service
1-877-946-7747

15 mg/mL; 1 mL vial
(NDC 0409-3793-01)

Available

Check wholesalers for availability
 

Shortage per Manufacturer: Manufacturing delay/Available

Other

Reverified 4/13/2014

15 mg/mL; 1 mL Carpuject
(NDC 0409-2288-31)
Available
30 mg/mL; 1mL vial
(NDC 0409-3795-01)

Available 

30 mg/mL; 1 mL Carpuject
(NDC 0409-2287-31)
Available
30 mg/mL; 2 mL Carpuject
(NDC 0409-2287-61)

Available

60 mg/mL; 2 ml vial
(NDC 0409-3796-01) 

Available
 

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Current Drug Shortages Index