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U.S. Department of Health and Human Services


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Drug-Drug Interactions: A Stepwise Approach

*These programs are not endorsed by the FDA



1. Take a medication history (AVOID mistakes)
2. Remember high risk patients
  • Any patient taking 2 medications
  • Anticonvulsants, antibiotics, digoxin, warfarin, amiodarone, etc
3. Check pocket reference
4. Consult pharmacists/drug info specialists
5. Check up-to-date computer program
  • Medical Letter Drug Interaction Program*
  • Clinical pharmacology (gsm.com)*
  • www.epocrates.com*



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