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U.S. Department of Health and Human Services

Drugs

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Cytochrome P450 2D6

Aklillu E et al. J Pharmacol Exp Ther 1996;278(1):441– 446

 

  • Absent in 7% of Caucasians, 1–2% non-Caucasians
  • Hyperactive in up to 30% of East Africans
  • Catalyzes primary metabolism of:
    • Codeine
    • Many ?-blockers
    • Many tricyclic antidepressants
  • Inhibited by:
    • Fluoxetine
    • Haloperidol
    • Paroxetine
    • Quinidine

 

 

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