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U.S. Department of Health and Human Services


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Costs Associated with ADRs

Johnson JA et al. Arch Intern Med 1995;155(18):1949–1956
Leape LL et al. N Engl J Med 1991;324(6):377–384
Classen DC et al. JAMA 1997;277(4):301–306



  • $136 BILLION yearly
  • Greater than total costs of cardiovascular or diabetic care
  • ADRs cause 1 out of 5 injuries or deaths per year to hospitalized patients
  • Mean length of stay, cost and mortality for ADR patients are DOUBLE that for control patients



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