International Cooperation on Cosmetics Regulation (ICCR) Meeting Outcomes (July 8-10, 2013)

July 17, 2013

Tokyo, Japan

The International Cooperation on Cosmetics Regulation (ICCR) held its seventh annual meeting (ICCR-7) from 8 to 10 July, 2013 in Tokyo, Japan to discuss issues related to cosmetics and cosmetic-like drug/quasi-drug products. ICCR is an international group of regulatory authorities for cosmetics from Canada, the European Union, the United States, and Japan (ICCR Members). This multilateral framework maintains the highest level of global consumer protection, while minimizing barriers to international trade. 

Representatives from China (AQSIQ) and from Brazil (ANVISA) participated as observers and presented information regarding their cosmetics regulatory systems.

At the Regulators-Industry Dialogue meeting, the regulators entered into a discussion with cosmetic industry trade associations from each of the jurisdictions.

The meeting focused on the following topics:

  • Membership and Observer Participation
  • Alternatives to Animal Testing
  • In silico Prediction Models for Cosmetic Safety Assessment
  • Nanomaterials
  • Trace Impurities
  • Endocrine Disruptors
  • Allergens

In addition, on 9 July, the ICCR Regulators hosted a stakeholders meeting.  Four animal rights groups participated in the session. In response to some of their concerns, ICCR will make available on its future website updated validated alternative methods to animal testing. 

The next ICCR meeting will be held in Ottawa, Canada in July of 2014.

Outcomes of the Meeting 

1. Membership and Observer Participation

  • ICCR invited China and Brazil to participate as observers of the ICCR process.

2. Alternatives to Animal Testing

  • Regulators received an updated report on International Cooperation on Alternative Test Methods (ICATM) activities.  
  • The industry report entitled “Inventory of validated Alternatives to Animal Testing worked upon by ICATM partners, applicable for cosmetic products and their ingredients in all ICCR Regions” prepared for ICCR was accepted. The Annex to the report was discussed and was accepted to be updated on a semi-annual basis. 

3. In silico Prediction Models for Cosmetic Safety Assessment

  • The working group (WG) of in silico prediction models for safety assessment made the progress report at the Regulators-Industry Dialogue Meeting. 
  • It was agreed that the WG will do a high level review of the in silico capability in relation to potential application in the assessment of cosmetic ingredients, highlighting any data/knowledge gaps and needs for further work toward ICCR-8.

4. Nanomaterials

  • The document “Characterization of Nanomaterials III-Insolubility, Biopersistence and Size Measurement in Complex Media” was presented.
  • The WG of Characterization of Nanomaterials will continue its work with a survey on scientific information to be conducted by the WG between ICCR-8 and ICCR-9.  The result will be reported at the ICCR-9.
  • The document “Safety Approaches to Nanomaterials in Cosmetics” was accepted and will be posted.

5.  Trace Impurities 

  • The document on lead was accepted, subject to editorial changes.
  • The documents on Mercury and 1,4-dioxane will continue to be a priority for ICCR. 

6.  Endocrine Disruptors 

  • Following the presentation and discussion, industry agreed to provide additional information and a proposal for future discussion. 

7.  Allergens

  • The WG presented a progress report at the Regulators-Industry Dialogue Meeting and intends to deliver a draft high level report for consideration at ICCR-8. 

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