International Cooperation on Cosmetics Regulation (ICCR), Outcomes of the Meeting Held July 10-13, 2012
Rockville, Maryland, U.S.A.
Alternatives to Animal Testing
In silico Prediction Models for Safety Assessment
Regulators received an updated report on International Cooperation on Alternative Test Methods (ICATM) activities. http://ihcp.jrc.ec.europa.eu/glossary/icatm-international-cooperation-on-alternative-test-methods
The ICCR acknowledges the usefulness of ICATM’s “Current Alternative Test Method Validation and Regulatory Acceptance Status Reportfor ICCR” as a reference for industry http://ihcp.jrc.ec.europa.eu/our_activities/alt-animal-testing/alt_test_cosmetics/ICATM%20Table%20of%20Assays%2021%20June%202012.pdf. The report will continue being updated on a semi-annual basis.
The revised document “Applicability of Animal Testing Alternatives in Regulatory Frameworks within ICCR Regions” will be posted.
- An overview was provided on the potential application of Quantitative Structure-Activity Relationship (QSAR) prediction models for cosmetic ingredient safety assessment. It was agreed that a working group will be established to further explore in silico models.
The document “Characterization of Nanomaterials II-Insolubility, Biopersistence and Size Measurement in Complex Media” will be posted.
The document “Safety Approaches to Nanomaterials in Cosmetics” will be posted.
It was agreed that both working groups will continue to consider additional issues pertinent to the characterization and safety of nanomaterials.
The documents on trace impurity levels of lead and 1,4-Dioxane in cosmetic products are undergoing final review.
The Traces WG will develop detailed recommendations for future work items.
The ICCR participants agreed to exchange information on this topic and to consider possible future work items.
- A working group will be established to develop a white paper compiling the regulatory approaches taken in each jurisdiction regarding allergens in cosmetics and personal care products.