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The 15th US-Japan Cellular and Gene Therapy Conference Agenda

on
Epigenetics in cancer

Natcher Conference Center
Building 45, Room E1/E2, National Institutes of Health
Bethesda, Maryland 20892

Thursday, February 23, 2012

The conference is jointly supported by the Center for Biologics Evaluation and Research (CBER), US Food and Drug Administration (FDA) and the Ministry of Education, Culture, Sports, Science and Technology, Japan under the US-Japan Cooperative Research Program. The goal of this conference is to exchange ideas on cutting edge areas of biomedical research and to enhance opportunities for collaborations among scientists from the US and Japan. The scientific theme of our joint annual meetings has been diverse. We have invited speakers from Japan and the US to discuss advances in this exciting field of research.

Seating is limited to 150 attendees and is on a first-come-first-served basis. No prior registration is required. For more information, please contact S. Rafat Husain by e-mailing syed.husain@fda.hhs.gov or phone at (301) 827-0475.
             

Program

8:00 a.m. – 8:30 a.m. Registration
Coffee and Breakfast
Moderator Syed R Husain, Senior Staff Scientist, Division of Cellular and Gene Therapies, CBER, US Food and Drug Administration, Bethesda, Maryland
8:30 a.m. – 8:35 a.m.
 		 Opening Remarks
Suzanne Epstein, Associate Director of Research, Office of Cellular, Tissue and Gene Therapies, CBER, US Food and Drug Administration, Bethesda, Maryland
8:35 a.m. – 8:40 a.m. Yoshikazu Ohya, Professor, Department of Integrated Biosciences Graduate School of Frontier Sciences, University of Tokyo, Japan

AM Session

Moderators Hiroyuki Aburatani, Professor, Research Center for Advanced Science and Technology, University of Tokyo, Toyko, Japan
Raj K Puri, Director,Division of Cellular and Gene Therapies, CBER, FDA, Bethesda, Maryland
8:40 a.m. – 9:10 a.m. Methylation dynamics in cancer
Hiroyuki Aburatani, Professor, Research Center for Advanced Science and Technology, University of Tokyo, Tokyo, Japan
9:10 a.m. – 9:40 a.m. Dynamic DNA methylation during cellular differentiation
Kathrin Muegge, Head, Epigenetics Section, National Cancer Institute, Frederick, Maryland
9:40 a.m. – 10:10 a.m. Instructive induction of aberrant DNA methylation by cellular environment, and its underlying mechanisms
Satoshi Yamashita, Division of Epigenomics, National Cancer Center Research Institute, Japan
10:10 a.m. – 10:40 a.m. Coffee Break
10:40 a.m. – 11:10 a.m. MTA1 master chromatin remodeling factor in cancer progression
Rakesh Kumar, Chair, Department of Biochemistry and Molecular Biology, George Washington Medical Center, Washington, DC
11:10 a.m. – 11:40 a.m. Epigenetic plasticity contributing to establishment of tissue heterogeneity in glioblastoma
Yutako Kondo, Division of Molecular Oncology, Aichi Cancer Center Research Institute, Nagoya, Japan

 

11:40 p.m. – 1:00 p.m. Lunch

PM Session

Moderators Stephen Baylin, Professor of Oncology and Medicine, and Deputy Director, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland
Yoshikazu Ohya, Professor, Department of Integrated Biosciences Graduate School of Frontier Sciences, University of Tokyo, Japan
1:00 p.m. – 1:30 p.m. The Cancer Epigenome – origins and translational implications
Stephen Baylin, Professor of Oncology and Medicine, and Deputy Director, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland
 
1:30 p.m. – 2:00 p.m. Epigenetic silencing of the microRNA biogenesis pathway in hepatocellular carcinoma
Tatsuhiro Shibata, Chief, Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan
2:00 p.m. – 2:30 p.m. Epigenetic status of cell-fate associated promoters during expansion of bone-marrow derived multipotent mesenchymal stromal cells
Deborah Hursh, Principal Investigator, Cellular and Tissue Therapy Branch, Division of Cellular and Gene Therapies, CBER, FDA, Bethesda, Maryland

2:30 p.m. – 3:00 p.m. Coffee Break

3:00 p.m. – 3:30 p.m. Genome-wide studies of p53 in embryonic stem cells
Jing Huang, Head, Cancer and Stem Cell Genetics, Laboratory of Cancer Biology and Genetics, National Cancer Institute, Bethesda, Maryland
3:30 p.m. – 4:00 p.m. Global DNA hypomethylation and transformation
Toshinobu Nakamura, Lecturer, Nagahama Institute of Bio-Science and Technology, and Graduate School of Medicine, Osaka University, Japan

Thank you for your participation!

Organizers: Syed R Husain, Ph.D.
Raj K Puri, M.D., Ph.D.
Tumor Vaccines and Biotechnology Branch
Division of Cellular and Gene Therapies
NIH Bldg. 29B, Room 2G07, HFM-735
Bethesda, Maryland, 20892
Ph. 301-827-0475; Fax 301-827-0449
syed.husain@fda.hhs.gov
raj.puri@fda.hhs.gov
 		 Yoshikazu Ohya, Ph.D.
Professor, Division of Biosciences
Department of Integrated Biosciences
Graduate School of Frontier Sciences
University of Tokyo
Bldg. FSB-101, 5-1-5 Kashiwanoha
Kashiwa, Chiba Prefecture 277-8562
Japan
ohya@k.u-tokyo.ac.jp

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