Fumonisins are naturally occurring toxins produced by the molds Fusarium moniliforme (F. verticillioides), F. proliferatum, and other Fusarium species that are common natural contaminants of corn. Fumonisins can cause leukoencephalomalacia in horses and pulmonary edema in pigs and have been linked to a variety of significant adverse health effects in other livestock and experimental animals. When provided in the diet at levels of 50 ppm and above, purified fumonisin B1 induced kidney tumors in male rats and liver tumors in female mice. Although human epidemiological studies are inconclusive at this time, based on a wide variety of significant adverse animal health effects, the association between fumonisins and human disease is possible. This page contains both CVM (animal feed) and CFSAN (human food) information on the subject.
- November 29, 2006
FDA Warns Horse Owners About Fumonisins in Horse Feed[ARCHIVED]
Federal Register Notices
Notice: Guidance for Industry: Fumonisin Levels in Human Foods and Animal Feeds; Availability
Federal Register, November 21, 2001, vol. 66, pp 56688-9