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U.S. Department of Health and Human Services

Animal & Veterinary

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FDA Veterinarian Newsletter July/August 2001 Volume XVI, No IV

by Marcia L. Headrick, D.V.M., M.P.H.

The FDA's Center for Veterinary Medicine (CVM) along with the USDA and CDC sponsored a two-day meeting on the results from the National Antimicrobial Resistance Monitoring System _ Enteric Bacteria (NARMS _ EB) and related antimicrobial resistance research. The meeting was held March 15 and 16, 2001, in Rockville, MD. The open scientific meeting was attended by over 200 registrants including representatives from Federal and State government agencies, academia, industry, commodity groups, public interest groups, and others interested in antimicrobial resistance research.

Dr. Linda Tollefson, Deputy Director, CVM, opened the meeting. Dr. Marcia Headrick, CVM NARMS Coordinator, organized the meeting. Members of the CVM Division of Epidemiology staff and other CVM staff were instrumental in the planning and coordination of the meeting. Representatives from FDA, USDA, and CDC served as moderators for the meeting and gave several of the presentations. The purpose of the meeting was to provide an opportunity for presentation of the results of antimicrobial research including results from the NARMS program.

The meeting was composed of seven sessions including two sessions on Salmonella resistance research and one session each on Government Agency Sponsored Research, Mitigation Strategies, Campylobacter, Environmental Issues, and Commensal Resistance Research. Twenty-four speakers were included in the agenda.

A poster session was coordinated by Dr. Charlotte Spires, Acting Director, CVM Division of Epidemiology. Poster titles included:

  • Presence of Enterococci on Grocery Products and Their Resistance Patterns
  • Antimicrobial Resistance of Salmonella Isolates Collected from Swine Farms with Different Antimicrobial Use Programs
  • Occurrence of Food Borne Pathogens and Antimicrobial Resistance Factors in Wild Turkeys
  • Antimicrobial Resistance In Salmonella Isolates from Exotic Animals,
  • NARMS 1997-1999
  • Changes in Antimicrobial Resistance in Campylobacter Isolated from Chicken Carcass Rinses from 1998 to 2000
  • Changes in Antimicrobial Resistance Profiles of Campylobacter Isolates _ 1994/95 and 2000
  • Antimicrobial Resistance in Campylobacter Isolated from Feedlot Cattle
  • Salmonella ser. Newport in Georgia
  • Metabolism and Fate of Ceftiofur used in Food Animals
  • Quinolone/Fluorquinolone Resistance in Veterinary Isolates of Salmonella enterica
  • Characterization of Multiple Drug Resistant Salmonella Newport Strains
  • Detection of Antibiotic Resistance Emerging from Natural Mutator Strains Using Kirby Bauer and Broth Dilutions Antibiotic Sensitivity Assays
  • Antimicrobial Resistance Among Enteric Bacteria Isolated from Human and Animal Wastes and Impacted Surface Waters: Comparison with NARMS Findings
  • Antimicrobial Susceptibility Testing of Campylobacter Isolated from Retail Meats by Agar Dilution and E-test.

Poster abstracts and presentation slides will be posted on the CVM NARMS website. Related meetings were held by CDC in 1999 and by USDA in 1998. The next meeting will be hosted by USDA, Agricultural Research Service, Antimicrobial Resistance Research Unit (ARRU) which conducts the animal arm of the NARMS.

Registrants were asked to provide an evaluation of the 2001 NARMS Scientific Meeting. Information received from the evaluations will be analyzed and provided to Dr. Paula Cray, Research Leader of the ARRU, for use in planning the next meeting.

The NARMS program plays an important role in the overall understanding of antimicrobial drug resistance. The NARMS primary role is to provide descriptive data on the extent and temporal trends in antimicrobial susceptibility in Salmonella and other enteric organisms from human and animal populations. However, NARMS also facilitates the identification of resistance in humans and animals as it arises, provides information on antimicrobial resistance to veterinarians and physicians, prolongs the life span of approved drugs by promoting the prudent and judicious use of antimicrobial drugs, and identifies areas for more detailed investigation. NARMS also aids in antimicrobial resistance research by providing a national source of enteric bacterial isolates that may be invaluable for research such as diagnostic test development, discovering new genes and molecular mechanisms associated with resistance, studying mobile gene elements, and for virulence and colonization studies.

For more information on the NARMS program, please contact Dr. Marcia Headrick of FDA, CVM at (706)546-3689. Additional information on the NARMS program is also available on the CVM NARMS web page. A brochure on the NARMS program is available by contacting the FDA Veterinarian at (301) 594-1755.

Dr. Headrick is an Epidemiologist with CVM's Division of Epidemiology. She is the FDA/CVM NARMS Coordinator.