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U.S. Department of Health and Human Services

Advisory Committees

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Questions for the Pathogen Load Meeting

  1. What is the contribution, as it relates to public health, of antimicrobial drugs to pathogen shedding and contamination of carcasses in the overall scheme of current animal production practices?
  2. Which antimicrobial drug use conditions in food-producing animals if any, are more (or less) likely to affect pathogen carriage and shedding?
  3. Do the committee members think that the potential for antimicrobial drug use to affect pathogen load is sufficient to warrant evaluation as part of the drug approval process? Why or why not?
  4. If committee members think that antimicrobial drug effects on pathogen load are sufficient to warrant evaluation, should specific prospective pathogen load studies be designed and interpreted to address these concerns?

If yes, what might be the approach for conducting such prospective studies?

If no, what other approaches should be considered to address these concerns?