February 22, 2010: Meeting of the Vaccines and Related Biological Products Advisory Committee Questions Document

Vaccines and Related Biological Products Advisory Committee
(2/22/2010)

Options for Strain Composition for 2010-2011 Influenza Vaccines

Influenza A (HINI)

• Retain current vaccine strain A/risbane/5912007 (HINl)-like virus
  • e.g., A/Brisbane/59/2007; A/South Dakota/6/2007
• Replace current vaccine strain with a pandemic A (H 1 N 1) vaccine virus A/California/712009-like virus
  • Other candidates?

Influenza A (H3N2)

• Retain current strain A/risbane/l 0/2007 (H3N2)-like virus
  • e.g., A/risbane/l0/2007; A/ruguay/716/2007
• Replace current vaccine strain with the Southern hemisphere vaccine virus
  A/Perthl16/2009 (H3N2)-like virus
  • e.g., A/erthl16/2009; A/Wisconsin/15/2009
  • Othercandidates?

Influenza B

• Retain current B/Brisbane/60/2008-like virus (BNictoria lineage)
  • e.g., B/Brisbane/60/2008; B/Brisbane/33/2008
• Replace current vaccine strain with alternative vaccine strain (B/Yamagata lineage)
  • Candidates?