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U.S. Department of Health and Human Services

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HIFU Simulator

HIFU Simulator determines many important characteristics of continuous wave, high-intensity focused ultrasound (HIFU) beams and their heating effects. This is done by integrating the axisymmetric KZK equation from the frequency-domain perspective. This results in a spatial distribution of pressure of each harmonic, taking into account beam diffraction, interference effects, power-law frequency-dependence of absorption and the corresponding phase velocity dispersion, and the nonlinear effects of higher harmonic generation/wavefront steepening. From these pressure fields the temporal average intensity and heating rate are calculated. The heating rate distribution may then be used as a source for the bioheat transfer (BHT) equation, which may be integrated to determine the temperature and thermal dose fields. 

Emphasis has been placed on both computational efficiency and user friendliness. HIFU_Simulator produces plots of salient quantities and outputs the computed variables to the Matlab workspace for user analysis and postprocessing. 

http://www.mathworks.com/matlabcentral/fileexchange/30886-high-intensity-focused-ultrasound-simulator

Please address any questions or suggestions to Dr Joshua Soneson at 301-796-2512 or joshua.soneson@fda.hhs.gov

 

Graph showing Temperature vs. length Graph showing thermal dose.

 

Graph showing temperature versus time.

 


Disclaimer: This software and documentation (the "Software") were developed at the Food and Drug Administration (FDA) by employees of the Federal Government in the course of their official duties. Pursuant to Title 17, Section 105 of the United States Code, this work is not subject to copyright protection and is in the public domain. Permission is hereby granted, free of charge, to any person obtaining a copy of the Software, to deal in the Software without restriction, including without limitation the rights to use, copy, modify, merge, publish, distribute, sublicense, or sell copies of the Software or derivatives, and to permit persons to whom the Software is furnished to do so. FDA assumes no responsibility whatsoever for use by other parties of the Software, its source code, documentation or compiled executables, and makes no guarantees, expressed or implied, about its quality, reliability, or any other characteristic. Further, use of this code in no way implies endorsement by the FDA or confers any advantage in regulatory decisions. Although this software can be redistributed and/or modified freely, we ask that any derivative works bear some notice that they are derived from it, and any modified versions bear some notice that they have been modified.