Research Project: Quantitation of Drug Response on Imaging Studies
The purpose of this study is to investigate and develop practical assessment strategies for estimating the extent of patient response to drugs using imaging. We are currently concentrating on understanding the fundamental performance limits for estimating, patient response parameters, such as volume and uptake, based on differences in imaging hardware, imaging technique and processing algorithms. We will use our knowledge of probability theory, along with the work of the Laboratory of Imaging Physics scientists, to determine error bounds for these estimation tasks. We will develop realistic lesion models and utilize phantom experiments to aid both the development of performance bounds, and to validate our results.
The resulting CT scans are analyzed in order to quantify sources of uncertainty in the volumetric assessment of lung nodules. Information from this project will be valuable in order to reduce the time needed to assess the response of tumors to drug therapy.