About FDA
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Informatics and Computational Safety Analysis Staff (ICSAS)
Organization and Responsibilities
About ICSAS
The Informatics and Computational Safety Analysis Staff (ICSAS) is part of CDER's Office of Pharmaceutical Science. ICSAS is an applied regulatory research unit that:
- Develops databases of toxicological and clinical endpoints
- Transforms data, developing rules for quantifying toxicological and clinical effects
- Evaluates structure activity relationship (SAR) and data mining software using ICSAS databases
- Works with software developers to develop toxicology and clinical effects prediction programs through research leveraging partnerships
- Reduces the use of animals in testing by eliminating non-critical laboratory studies
- Facilitates the review process by making better use of accumulated scientific knowledge
- Supplies tools to the pharmaceutical industry to develop better means to identify and eliminate compounds with potentially significant adverse properties early in the drug discovery and development process
Organization and Responsibilities
| Informatics and Computational Safety Analysis Director | Joseph F. Contrera, Ph.D. Joseph.Contrera@fda.hhs.gov |
| Computational Toxicology Manager | Edwin J. Matthews, Ph.D. Edwin.Matthews@fda.hhs.gov |
| Database Manager | R. Daniel Benz, Ph.D. R.Daniel.Benz@fda.hhs.gov |
| Computational Toxicologist | Naomi L. Kruhlak, Ph.D. Naomi.Kruhlak@fda.hhs.gov |
- Database Projects
- Chemical Structure Similarity Searching
- The Computational Toxicology Program and ComTox Consulting Service
- ComTox Regulatory Application of ICSAS MCASE/MC4PC-ES by the Center for Food Safety and Applied Nutrition
- Application of Computational Toxicology to Assess Clinical Adverse Drug Reactions
- Publications
Contact Us
Please send questions or comments concerning the contents of this page to Dan Benz at R.Daniel.Benz@fda.hhs.gov
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