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U.S. Department of Health and Human Services

About FDA

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Director: Carl E. Cerniglia, Ph.D.

The Division of Microbiology at NCTR serves a multipurpose function with specialized expertise to perform fundamental and applied research in microbiology as well as to respond to microbial surveillance and diagnostic needs for research projects within NCTR and FDA. The Division of Microbiology consists of research scientists, research support staff, postdoctoral fellows, undergraduate and graduate students, visiting scientists, and program support specialists. The Microbiology Division has the staff and facilities to help address the scientific challenges encountered by FDA and other government organizations. Examples of the research within the Division and collaborative research with scientists from other NCTR Divisions, FDA Centers, academic institutions, and other federal agencies are described below. Projects are based on FDA priorities and programmatic expertise. The research program is divided into five areas:

  1. food safety, food biosecurity, and methods development
  2. antimicrobial resistance in foodborne and commensal bacteria
  3. intestinal microflora and host interactions
  4. environmental biotechnology
  5. microbiological surveillance and diagnostic support of research
Ongoing Research Projects
  • Antimicrobial-Resistance Genetics of "Emerging" Salmonella Enterica Serovar Javiana Phenotypes Involved in Clinical and Food-Related Outbreaks (E0726701)
  • Application of Co-Culture and Simulated-Vaginal Models to Elucidate the Inhibitory Properties of Naturally Occurring and Bioengineered Strains of Lactobacillus Toward Toxic-Shock Syndrome Toxin-1 Producing Strains of Staphylococcus aureus (E0728601)
  • Characterization of plasmid Associated antimicrobial resistance in Salmonella enterica serovars associated with poultry and human infections (E0733501)
  • Co-Display of Hemagglutinin and CD154 on the Surface of Yeast Cells as a Vaccine against Avian Influenza (E0733301)
  • Effects of Phytoestrogens on Gene Expression Responses of Vaginal Epithelial Cells After Contact With Candida albicans (E0740601)
  • Evaluate the impact of Deepwater Horizon oil contaminated Gulf seafood residues in edible tissues on the human intestinal microbiota of the consumer (E0742801)
  • Gene Expression Responses by Avirulent Bacillus anthracis and Human Epithelial cells during initial host-pathogen contact (E0733401)
  • Impact of Antimicrobial Residues on the Human Gastrointestinal Tract Microbiota (E0732701)
  • Investigating the Mechanisms of Drug Resistance and Pathogenicity in Clinical Escherichia coli Isolates from Veterinary Sources (E0744901)
  • Isolation and Characterization of Fluoroquinolone-Resistant Bacteria from Shrimp (E0730701)
  • Maintenance of Germfree BALB/c Mice in Isolators for Use in Future Protocols (E0736701)
  • Mechanistic Evaluation of the Induction of Lymphoproliferation and Apoptosis Inhibition by Probiotic Bacteria in Mice Infected with Salmonella Enterica (E0727601)
  • Microarray analysis for the detection of targeted gene expression changes resulting from exposure of Clostridium perfringens to fluoroquinolones (E0731101)
  • Microbial Degradation of Fluoroquinolone Antimicrobial Agents (E0722701)
  • Microbiological Diagnostic Methods: Development, Testing, & Evaluation (E0026200)
  • Molecular and seroepidemiology of coronavirus and disease spectrum in adults, children, domestic animals and wildlife in the US (E0738001)
  • Quantification Proteomic, Transcriptomic, and Phenotypic Microarray Analysis of C. jejuni for the Identification of Colonization Factors in Poultry (E0735601) 

The NCTR Annual Report contains information on the latest accomplishments and plans for the Division of Microbiology as well as project and publication listings.


Contact FDA

National Center for Toxicological Research

Food and Drug Administration

3900 NCTR Road

Jefferson, AR 72079