About FDA

Microbiology

Director: Carl E. Cerniglia, Ph.D.

The Division of Microbiology's goals are to perform fundamental and applied research to address critical issues in support of the FDA mission. The Division's research projects are based on expertise of division staff and consultation with scientists from other FDA Centers, regulatory agencies, academia, and industry. The Division staff includes research scientists, research support staff, postdoctoral fellows, undergraduate and graduate students, visiting scientists, and program support specialists. The Division staff has the facilities and equipment to help address the scientific challenges encountered by FDA and other government organizations. The Division of Microbiology scientists are actively engaged in research addressing FDA issues with special emphasis on:

  1. Developing methods to detect, identify, and characterize foodborne pathogens
  2. Determining antimicrobial resistance and virulence mechanisms of microbial pathogens
  3. Using state-of-the-art molecular biological approaches to monitor interactions between human microbiota, antimicrobial agents, food contaminants, food additives, food supplements, and FDA-regulated products
  4. Studies impacting women's health
  5. Improving environmental risk assessments of priority pollutants, including polycyclic aromatic hydrocarbons and drugs, by integrating systems biology approaches
  6. Developing new research initiatives to support the FDA's Center for Tobacco Products
  7. Nanotechnology
     
Ongoing Research Projects
 
  • Antimicrobial properties of ZnO and TiO2 nanoparticles (NPs) against multidrug-resistant Staphylococcus and Enterococcus spp. and their cytotoxic and genotoxic potential in bacteria and normal human epidermal keratinocytes (NHEK) and primary intestinal cells (E0751501)
  • Antimicrobial susceptibilities of Clostridium perfringens strains isolated from different sources and genetic characterizations of resistance (E0751601)
  • Assessment of size and shape dependent-toxicity of silver nanoparticles as measured by changes in the permeability at the gastrointestinal surface (E0750601)
  • Characterization of plasmid Associated antimicrobial resistance in Salmonella enterica serovars associated with poultry and human infections (E0733501)
  • Chromogenic agar and PCR identification of enterotoxigenic Bacullus cereus from naturally contaminated dietary supplements (E0748301)
  • Co-Display of Hemagglutinin and CD154 on the Surface of Yeast Cells as a Vaccine against Avian Influenza (E0733301)
  • Detection of cytolethal distending toxin (cdtB), pltA and pltB homologs of components of the pertussis toxin genes by PCR and studies on functionnality of cdtB in non-typhoidal Salmonella spp. (E0739601)
  • Development of an infectivity assay to detect human norovirus from contaminated food (E0745801)Does the durable nanoparticle bioaccumulation in macrophages increase susceptibility to bacterial infection (E0753601)
  • Effects of Phytoestrogens on Gene Expression Responses of Vaginal Epithelial Cells After Contact With Candida albicans (E0740601)
  • Evaluate the impact of Deepwater Horizon oil contaminated Gulf seafood residues in edible tissues on the human intestinal microbiota of the consumer (E0742801)
  • Evaluation of methods used to measure growth of Staphylococcus aureus and the production of toxic shock syndrome toxin-1 as influenced by menstrual tampons (E0754401)
  • Exploring strategies for resuscitation and enrichment of Burkholderia cepacia complex strains in pharmaceutical products (E0749801)
  • Gene Expression Responses by Avirulent Bacillus anthracis and Human Epithelial cells during initial host-pathogen contact (E0733401)
  • Graphene induced toxicity on the population of intestinal microbiota and gut-associated immune response (E0754701)
  • Immunological effects of nanoparticles on induction of pro-inflammatory responses to Candida albicans by vaginal epithelial cells (E0752001)
  • Impact of Antimicrobial Residues on the Human Gastrointestinal Tract Microbiota (E0732701)
  • Investigating the Mechanisms of Drug Resistance and Pathogenicity in Clinical Escherichia coli Isolates from Veterinary Sources (E0744901)
  • Maintenance of Germfree BALB/c Mice in Isolators for Use in Future Protocols (E0736701)
  • Molecular and seroepidemiology of coronavirus and disease spectrum in adults, children, domestic animals and wildlife in the US (E0738001)
  • Microbial genetics of non-O157:H7 Shiga-like toxin producing Escherichia coli (STEC) isolated from humans and foods (E0735701)
  • Quantification Proteomic, Transcriptomic, and Phenotypic Microarray Analysis of C. jejuni for the Identification of Colonization Factors in Poultry (E0735601) 
  • Reducing health risks from antimicrobial-resistant bacteria by eliminating environmental reservoirs of ressistance (E0738201)

The NCTR Annual Report contains information on the latest accomplishments and plans for the Division of Microbiology as well as project and publication listings.

Contact FDA

870-543-7000
National Center for Toxicological Research

Food and Drug Administration

3900 NCTR Road

Jefferson, AR 72079

Page Last Updated: 06/26/2014
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