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FY 2010 Scientific Publications

  • Aidoo, A. and Manjanatha, M. (2011). Influence of Dietary Isoflavones Genistein and Daidzein on Genotoxicity and Mammary Carcinogenesis in Rats Exposed to the Model Carcinogen 7,12-dimethylbenz(a)anthracene (DMBA). Vegetables, Whole Grains and Their Derivatives in Cancer Prevention. 2: 142-173.
  • Ali, S.F., Jiang, H., Rongzhu, L., Milatiovic, D., and Aschner, M. (2009). Methamphetamine dysregulates redox status in primary astrocyte and neuronal rat cultures. American Journal of Neuroprotection and Neurodegeneration. 1: 52-59.
  • Alusta, P.S., Im, I., Pearce, B.A., Beger, R., Kretzer, R.M., Buzatu, D.A., and Wilkes, J.G. (2010). Improving proton MR spectroscopy of brain tissue for noninvasive diagnostics. Journal of Magnetic Resonance Imaging. 32: 818-829.
  • Andrade, J.E., Twaddle, N.C., Helferich, W.G., and Doerge, D.R. (2010). Absolute Bioavailability of Isoflavones from Soy Protein Isolate-Containing Food in Female BALB/C Mice. Journal Agricultural Food Chemistry. 58(7): 4529-36.
  • Antunes, A.M., Godinho, A.L., Martins, I.L., Justino, G.C., Beland, F.A., and Marques, M.M. (2010). Amino acid adduct formation by the nevirapine metabolite, 12-hydroxynevirapine—a possible factor in nevirapine toxicity. Chemical Research in Toxicology. 23(5): 888-899.
  • Antunes, A.M., Godinho, A.L., Martins, I.L., Oliveira, M., Gomes, R., Coelho, A., Beland, F.A., and Marques, M.M. (2010). Protein adducts as prospective biomarkers of nevirapine toxicity. Chemical Research in Toxicology. 23 (11): 1714-1725.
  • Arasappan, D., Fang, H., Perkins, R.G., and Tong, W. (2010). Interpretation of toxicogenomics data. Comprehensive Toxicology. 2(34): 663-683.
  • Beger, R., Sun, J., and Schnackenberg, L. (2010). Metabolomics approaches for discovering biomarkers of drug-induced hepatotoxicity and nephrotoxicity. Toxicology and Applied Pharmacology. 243: 154-166.
  • Binienda, Z.K., Beaudoin, M.A., Gough, B.J., Ali, S.F., and Virmani, A. (2010). Assessment of 3-nitropropionic acid-evoked peripheral neuropathy in rats: neuroprotective effects of acetyl-L-carnitine and resveratrol. Neuroscience Letters. 480: 117-121.
  • Boctor, S.Y. and Ferguson, S.A. (2010). Altered adult locomotor activity in rats from phencyclidine treatment on postnatal days 7, 9, and 11, but not repeated ketamine  treatment on postnatal day 7. Neurotoxicology and Teratology. 31: 42-54.
  • Castillo-Lluva, S., Tatham, M.H., Jones, R.C., Jaffray, E.G., Edmondson, R.D., Hay, R.T., and Malliri, A. (2010). SUMOylation of the GTPase Rac1 is required for optimal cell migration. Nature Cell Biology. 12(11):1078-85.
  • Chan, Y., Patterson, T.A., Bouaynaya, N., Chowdhury, P., Lesing, S., and Tarasenko, O. (2010). Predictive models of cognitive outcomes of developmental insults. AIP Conference Proceedings. 1229: 87-93.
  • Chen, H., Feng, J., Kweon, O., Xu, H., and Cerniglia, C.E. (2010). Identification and molecular characterization of a novel flavin-free NADPH preferred azoreductase encoded by azoB in Pigmentiphaga kulllae K24. BMC Biochemistry. 11: 13.
  • Chen, J.J. and Tsai, C. (2010). Testing Significance of a Class of Genes. Computational and Statistical Methods to Analyze Complex Diseases. Book Chapter: 167-180.
  • Chen, T. (2010). The role of microRNA in chemical carcinogenesis. Journal of Environment Science and Health, Part C Environmental Carcinogenesis and Ecotoxicology Reviews. 28: 89-124.
  • Chen, T., Mei, N. and Fu, P.P. (2010). Genotoxicity of Pyrrolizidine Alkaloids. Journal of Applied Toxicology. 30(3): 183-96.
  • Chiang, H.H., Yin, J., Xia, Q., Zhao, Y., Fu, P.P., Wen, K., and Yu, H. (2010). Photoirradiation of azulene and guaiazulene—Formation of reactive oxygen species and induction of lipid peroxidation. Journal of Photochemistry and Photobiology. 211: 123-128.
  • Cimafranca, M.A., Davila, J., Ekman, G.C., Neese, S.L., Woodling, K.A., Flaws, J.A., Schantz, S., Doerge, D.R., and Cooke, P.S. (2010). A physiological mouse model for testing neonatal effects of the soy phytoestrogen genistein. Biology of Reproduction. 83: 114-121.
  • Cuevas, E., Lantz, S., Newport, G.D., Divine, B.L., Wu, Q., Paule, M.G., Tobon-Velasco, J.C., Ali, S.F., and Santamaria, A. (2010). On the early toxic effect of quinolinic acid: involvement of RAGE. Neuroscience Letters. 474: 74-78.
  • David, D.E., Lynne, A.M., Han, J., and Foley, S.L. (2010). Evaluation of virulence factor profiling in the characterization of veterinary Escherichia coli. Applied and Environmental Microbiology. 76 (22):7509-13.
  • Desai, V.G. (2011). Mitochondria-specific mouse gene array and its application in toxicogenomics. Systems Toxicology: A Handbook. 1 (3): 125-146.
  • Ding, D., Xu, L., Fang, H., Hong, H., Perkins, R.G., Harris, S.C., Bearden, E.D., Shi, L., and Tong, W. (2010). The EDKB, an established knowledge base for endocrine disrupting chemicals. BMC Bioinformatics. 11 Suppl 6:S5.
  • Dobrovolsky, V.N., Miura, D., Heflich, R.H., and Dertinger, S.D. (2010). The in vivo PIG-A gene mutation assay, a potential tool for regulatory safety assessment. Environmental Molecular Mutagenesis. 51: 825-835.
  • Doerge, D.R., Twaddle, N.C., Vanlandingham, M., and Fisher, J.W. (2010). Pharmacokinetics of Bisphenol A in neonatal and adult Sprague-Dawley rats. Toxicology and Applied Pharmacology. 247(2): 158-165.
  • Doerge, D.R., Twaddle, N.C., Woodling, K.A., and Fisher, J.W. (2010). Pharmacokinetics of Bisphenol A in neonatal and adult rhesus monkeys. Toxicology Applied Pharmacology. 248(1): 1-11.
  • Fan, X., Shi, L., Fang, H., Cheng, Y., Perkins, R.G., and Tong, W. (2010). DNA microarrays are predictive of cancer prognosis: a re-evaluation. Clinical Cancer Research. 16(2): 629-636.
  • Fang, H., Bushel, P.R., Woods, M., and Zhang, J. (2010). A comparison of batch effect removal methods for enhancement of prediction performance using MAQC-II microarray gene expression data. The Pharmacogenomics Journal. 10: 278-291.
  • Fang, H., Shi, L., and Tong, W. (2010). Consistency of predictive signature genes and classifiers generated using different microarray platforms. The Pharmacogenomics Journal. 10: 247-257.
  • Fang, H., Xu, Z., Ding, D., Jackson, S.A., Patel, I., Frye, J.G., Zou, W., Nayak, R.R., Foley, S.L., Chen, J.J., Su, Z., Ye, Y., Turner, S.A., Harris, S.C., Zhou, G., Cerniglia, C.E., and Tong, W. (2010). An FDA bioinformatics tool for microbial genomics research on molecular characterization of bacterial foodborne pathogens using microarrays. BMC Bioinformatics. 11(Supp 6): S4.
  • Fang, J., Stingley, R.L., Beland, F.A., Harrouk, W., Lumpkins, D.L., and Howard, P. (2010). Occurrence, efficacy, metabolism, and toxicity of triclosan. Journal of Environmental Carcinogenesis and Ecotoxicology Reviews/Journal of Environmental Science and Health-Part C. 28(3): 147-71.
  • Ferguson, S.A. and Berry, K.J. (2010). Chronic oral treatment with isotretinoin alters measures of activity, but not anxiety in male and female rats. Neurotoxicology and Teratology. 32: 573-578.
  • Ferguson, S.A. and Boctor, S.Y. (2010). Cocaine responsiveness or anhedonia in rats treated with methylphenidate during adolescence. Neurotoxicology and Teratology. 32: 432-442.
  • Formeister, E.J., Threadgill, D., Shpyleva, S.I., Pogribny, I.P., and Rusyn, I. (2010). Comparative analysis of promoter methylation and gene expression endpoints between tumorous and non-tumorous tissues from HCV-positive patients with hepatocellular carcinoma. Mutation Research. 692(1-2): 26-33.
  • Fu, P.P., Chou, M.W., Churchwell, M.I., Wang, Y., Zhao, Y., Xia, Q., Gamboa Da Costa, G., Marques, M.M., Beland, F.A., and Doerge, D.R. (2010). High-performance liquid chromatography electrospray ionization tandem mass spectrometry for the detection and quantitation of pyrrolizidine alkaloid-derived DNA adducts in vitro and in vivo. Chemical Research in Toxicology. 23(3): 637-652.
  • Gamboa Da Costa, G., Singh, R., Volker, A.M., Mirza, A., Takamura-Enya, T., Farmer, P.B., and Phillips, D.H. (2009). Quantification of 3-nitrobenzanthrone-DNA adducts using online column-switching HPLC-electrospray tandem mass spectrometry. Chemical Research in Toxicology. 22(11): 1860-8.
  • Garey, J.D. and Paule, M.G. (2010). Effects of Chronic Oral Acrylamide Exposure on Incremental Repeated Acquisition (Learning) Task Performance in Fischer 344 Rats. Neurotoxicology and Teratology. 32: 220-225.
  • Goodsaid, F.M., Amur, S., Aubrecht, J., Burczynski, M.E., Carl, K., Catalano, J., Charlab, R., Close, S., Cornu-Artis, C., Essioux, L., Fornace, A.J., Jr, Hinman, L., Hong, H., Hunt, I., Jacobson-Kram, D., Jawaid, A., Laurie, D., Lesko, L., Li, H.H., Lindpaintner, K., Mayne, J., Morrow, P., Papaluca-Amati, M., Robison, T.W., Roth, J., Schuppe-Koistinen, I., Shi, L., Spleiss, O., Tong, W., Truter, S.L., Vonderscher, J., Westelinck, A., Zhang, L., and Zineh, I. (2010). Voluntary exploratory data submissions to the U.S. FDA and the EMA: experience and impact. Nature Reviews Drug Discovery. 9: 435-445.
  • Goodsaid, F.M. and Mendrick, D. (2010). Translational medicine and the value of biomarker qualification. Science Translational Medicine. 2(47): 47-44.
  • Guo, L., Fu, P.P., Fuscoe, J., and Mei, N. (2010). Application of DNA microarray in studies of herbal dietary supplements. Handbook of Systems Toxicology.
  • Guo, L., Mei, N., Liao, W., Chan, P.C., and Fu, P.P. (2010). Ginkgo biloba extract-induced gene expression changes in xenobiotics metabolism and Myc-centered network. OMICS. 14(1): 75-90.
  • Guo, L., Mei, N., Xia, Q., Chen, T., Chan, P., and Fu, P.P. (2010). Gene expression profiling as an initial approach for mechanistic study of toxicity and tumorigenicity of herbal plants and herbal dietary supplements. Journal of Environmental Health Sciences, Part C. 28(1): 60-87.
  • Guo, L., Shi, Q., Dial, S.L., Xia, Q., Mei, N., Li, Q., Chan, P.C., and Fu, P.P. (2010). Gene expression profiling in male B6C3F1 mouse livers exposed to kava identifies changes in drug metabolizing genes and potential mechanisms linked to kava toxicity. Food and Chemical Toxicology. 48: 686-696.
  • Hansen, D.K. (2010). Developmental Toxicity of Antiepileptic Drugs. Comprehensive Toxicology, 2nd edition. 12: 177-187.
  • Hart, M.E., Hart, M.J., and Roop, A.J. (2009). Genotypic and phenotypic assessment of hyaluronidase among type strains of a select group of Staphylococcus  species. International Journal of Microbiology. 2009: 1-8.
  • Holthoff, J.H., Woodling, K.A., Doerge, D.R., Burns, S.T., Hinson, J.A., and Mayeux, P.R. (2010). Resveratrol, a dietary polyphenolic phytoalexin, is a functional scavenger of peroxynitrite. Biochemical Pharmacology. 80(8): 1260-1265.
  • Hong, H., Goodsaid, F.M., Shi, L., and Tong, W. (2010). Molecular biomarker:  a U.S. FDA effort. Biomarkers in Medicine. 4(2): 215-225.
  • Hong, H., Shi, L., Su, Z., Ge, W., Jones, W.D., Czika, W., Miclaus, K., Lambert, C.G., Vega, S.C., Zhang, J., Ning, B., Liu, J., Green, B., Xu, L., Fang, H., Perkins, R., Lin, S.M., Jafari, N., Park, K., Ahn, T., Chierici, M., Furlanello, C., Zhang, L., Wolfinger, R.D., Goodsaid, F., and Tong, W. (2010). Assessing sources of inconsistencies in genotypes and their effect on genome-wide association studies with HapMap samples. The Pharmacogenomics Journal. 10(4): 364-374.
  • Hong, H., Su, Z., Ge, W., Shi, L., Perkins, R.G., Fang, H., Mendrick, D., and Tong, W. (2010). Evaluating variations of genotype calling: a potential source of spurious associations in genome-wide association studies. Journal of Genetics. 89(1): 55-64.
  • Hong, H., Xu, L., and Tong, W. (2010). Assessing consistency between versions of genotype-calling algorithm Birdseed for the genome-wide human SNP Array 6.0 using HapMap samples. Advances in Computational Biology. 680(4): 355-360.
  • Hsu, A., Bray, T., Helferich, W., Doerge, D.R., and Ho, E. (2010). Differential effects of whole soy extract and soy isoflavones on apoptosis in prostate cancer cells. Exerimental Biology and Medicine. 235(1): 90-7.
  • Iverson, A.R., Boyd, K.L., McAuley, J.L., Plano, L.R., Hart, M.E., and Mccullers, J.A. (2011). Influenza virus primes mice for pneumonia from Staphylococcus aureus. Journal of Infectious Diseases. 203(6): 880-8.
  • Jackson, L.S., Zhang, Z., and Tolleson, W.H. (2010). Thermal stability of ricin in orange and apple juices. Journal of Food Science. 75: T65-T71.
  • Kaput, J. (2010). Challenges of molecular nutrition research 6: The Nutritional Phenotype database to store, share, and evaluate nutritional systems biology studies. Genes and Nutrition. 5(3):189-203.
  • Kaput, J. (2010). Using genetics to tackle malnutrition. Science and Development Network. January 20, 2010: Epub.
  • Kaput, J., Van Ommen, B., Perozzi, G., Evelo, C., and Cotton, R. (2010). Connecting the Human Variome Project to Nutrigenomics. Genes and Nutrition. 5(4): 275–283.
  • Kodell, R.L. and Chen, J.J. (2010). Is pre-market identification of hepatotoxic drugs and sensitive patients possible based on hi-dimensional ‘omic’ data? Future Medicine—Personalized Medicine. 7: 8.
  • Kulkarni, R.M., Petibone, D., Chang, C., Chen, J.J., Tolleson, W.H., Melchior, W.B., Churchwell, M.I., Beland, F.A., and Morris, S.M. (2011). Effect of p53 Genotype on Gene Expression and DNA Adducts in ENU-Exposed Mice. Handbook of Systems Toxicology. Volume 1: 53-66. ISBN: 978-0-470-68401-6.
  • Kutanzi, K.R., Koturbash, I., Bronson, R.T., Pogribny, I.P., and Kovalchuk, O. (2010). Imbalance between apoptosis and cell proliferation during early stages of mammary gland carcinogenesis in ACI rats. Mutation Research. 694(1-2): 1-6.
  • Kwekel, J.C., Desai, V.G., Moland, C.L., Branham, W.S., and Fuscoe, J. (2010). Age- and sex- dependent changes in liver gene expression during the life cycle of the rat. BMC Genomics. 11:675.
  • Kweon, O., Kim, S., Freeman, J.P., Song, J., Baek, S., and Cerniglia, C.E. (2010). Substrate specificity and structural characteristics of the novel rieske nonheme iron aromatic ring-hydroxylating oxygenases NidAB and NidA3B3 from Mycobacterium vanbaalenii PYR-1. Molecular BIology. 1(2): 1-11.
  • Levis, S., Strickman-Stein, N., Doerge, D.R., and Krischer, J. (2010). Design and baseline characteristics of the soy phytoestrogens as replacement estrogen (SPARE) study—a clinical trial of the effects of soy isoflavones in menopausal women. Contemporary Clinical Trials. 31(4): 293-302.
  • Li, Z., Branham, W.S., Dial, S.L., Wang, Y., Guo, L., Shi, L., and Chen, T. (2010). Genomic analysis of microRNA time-course expression in liver of mice treated with genotoxic carcinogen N-ethyl-N-nitrosourea. BMC Genomics. 11: 609.
  • Liao, G., Wen, Z., Irizarry, K., Huang, Y., Mitsouras, K., Darmani, M., Leon, T., Shi, L., and Bi, X. (2010). Abnormal gene expression in cerebellum of Npc1-/- mice during postnatal development. Brain Research. 1325: 128-140.
  • Lin, G., Xia, Q., Li, N., and Fu, P.P. (2011). Hepatotoxicity and tumorigenicity induced by metabolic activation of pyrrolizidine alkaloids in herbs. Current Drug Metabolism. Publication pending.
  • Lin, W. and Chen, J.J. (2010). Power and sample-size estimation in microarray studies. BMC Bioinformatics. 11:48.
  • Lin, Y., Barker, E., Kislow, J., Kaldhone, P., Stemper, M.E., Pantrangi, M., Moore, F.M., Hall, M., Fritsche, T.R., Novicki, T., Foley, S.L., and Shukla, S.K. (2010). Evidence of multiple virulence subtypes in nosocomial and community-associated MRSA genotypes in companion animals from the upper midwestern and northeastern United States. Clinical Medicine and Research. September 2, 2010: Epub ahead of print.
  • Liu, F., Paule, M.G., Ali, S.F., and Wang, C. (2011). Ketamine-induced neurotoxicity and changes in gene expression in the developing rat brain. Current Neuropharmacology. 9: 256-261.
  • Liu, F., Zou, X., Sadovova, N.V., Zhang, X., Shi, L., Guo, L., Qian, F., Wen, Z., Patterson, T.A., Hanig, J.P., Paule, M.G., Slikker, W., and Wang, C. (2010) Changes in gene expression after phencyclidine administration in developing rats: a potential animal model for schizophrenia. International Journal of Developmental Neuroscience. August 5, 2010: Epub ahead of print.
  • Lucas, P.W., Schmit, J.M., Peterson, Q.P., West, D.C., Hsu, D.C., Novotny, C.J., Dirikolu, L., Churchwell, M.I., Doerge, D.R., Garrett, L.D., Hergenrother, P.J., and Fan, T.M. (2010). Pharmacokinetics and derivation of an anticancer dosing regimen for PAC-1 in healthy dogs. Investigational New Drugs. May 25, 2010: Epub ahead of print.
  • Lyn-Cook, Jr., L.E., Tareke, E., Word, B.R., Starlard-Davenport, A., Lyn-Cook, B.A., and Hammons, G.J. (2011). Food contaminant acrylamide increases expression of cox-2 and nitric oxide synthase in breast epithelial cells. Toxicology and Industrial Health. 27(1): 11-8.
  • MAQC Consortium, T. (2010). The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models. Nature Biotechnology. 28: 827-838.
  • Mei, N., Guo, L., Luan, Y., Fu, P.P., Fuscoe, J., and Chen, T. (2010). Metabolism, genotoxicity, and carcinogenicity of comfrey. Journal of Toxicology and Environmental Health, Part B: Critical Reviews. 13(7-8): 509-26.
  • Mei, N., Guo, X., Verkler, T., Chen, Y., Polzin, G.M., Richter, P., Moore, M., and Mei, N. (2010). Mutagenicity of 11 cigarette smoke condensates in two versions of the mouse lymphoma assay. Mutagenesis. Oct 27, 2010: Epub ahead of print.
  • Mei, N., McDaniel, L.P., Dobrovolsky, V.N., Guo, X., Shaddock, J.G., Mittelstaedt, R.A., Azuma, M., McGarrity, L.J., Doerge, D.R., and Heflich, R.H. (2010). The genotoxicity of acrylamide and glycidamide in Big Blue Rats. Toxicological Sciences. 115(2): 412-421.
  • Mei, N., McDaniel, L.P., Wang, R., Manjanatha, M., Shelton, S.D., and Doerge, D.R. (2010). Mutagenicity of Acrylamide and glycidamide in the testes of Big Blue Mice. Toxicological Sciences. 117(1): 72-80.
  • Mei, N., Xia, Q., Fu, P.P., Moore, M., and Chen, T. (2010). Cytotoxicity and mutagenicity of retinol with ultraviolet A irradiation in mouse lymphoma cells. Toxicology In Vitro. 24(2): 439-44.
  • Melendez, S., Hanning, I., Han, J., Nayak, R.R., Clement, A., Wooming, A., Hererra, P., Jones, F., Foley, S.L., and Ricke, S. (2010). Salmonella enterica isolates from pasture-raised poultry exhibit antimicrobial resistance and class I integrons. Journal of Applied Microbiology. 109: 1957-1966.
  • Mendoza, M. (2010). The path to personalized medicine—future challenges and opportunities for health information management professionals in the post-genomic era. Journal of the American Health Information Management Association. 11: 38-42.
  • Meng, F., Parsons, B.L., Andersen, M.E., Mckinzie, P.B., Bermudez, E., and Clewell, H. (2010). Measurement of tumor-associated mutations in the nasal mucosa of rats exposed to varying doses of formaldehyde. Regulatory Pharmacology and Toxicology. 57: 274-283.
  • Mercer, K.E., Apostolov, E.O., Gamboa Da Costa, G., Yu, X., Lang, P.M., Roberts, D.W., Davis, W., Basnakian, A.G., Kadlubar, F.F., and Kadlubar, S. (2010). 4-sulfoxy-tamoxifen produced in SULT1A1 expressing breast-cancer cells induces apoptosis. International Journal of Cancer. 1: 92-103.
  • Miclaus, K., Chierici, M., Lambert, C.G., Zhang, L., Vega, S.C., Hong, H., Yin, S., Furlanello, C., Wolfinger, R.D., and Goodsaid, F.M. (2010). Variability in GWAS analysis: the impact of genotype calling algorithm inconsistencies. The Pharmacogenomics Journal. 10: 324-335.
  • Miclaus, K., Wolfinger, R.D., Vega, S.C., Chierici, M., Furlanello, C., Lambert, C.G., Hong, H., Zhang, L., Yin, S., and Goodsaid, F.M. (2010). Batch effects in the BRLMM genotype calling algorithm influence GWAS results for the Affymetrix 500K array. The Pharmacogenomics Journal. 10: 336-346.
  • Moore, M., Thybaud, V., MacGregor, J.T., Dearfield, K.L., and Douglas, G. (2010). Strategies in case of positive in vivo results in genotoxicity testing. Mutation Research. Sep 17, 2010: Epub ahead of print.
  • Nawaz, M.S., Khan, S.A., Khan, A.A., Sung, K., Tran, Q., Kerdahi, K.F., and Steele, R.S. (2010). Detection and characterization of virulence genes and integrons in Aeromonas veronii isolated from catfish. Food Microbiology. 27: 327-331.
  • Nayak, R.R., Foley, S.L. (2011). Campylobacter jejuni. FDA.gov. Chapter 2.
  • Neese, S.L., Wang, V.C., Doerge, D.R., Woodling, K.A., Helferich, W.G., Korol, D.L., and Schantz, S. (2010). Impact of dietary genistein and aging on executive function in rats. Neurotoxicology and Teratology. 32(2): 200-11.
  • Oberthuer, A., Juraeva, D., Li, L., Kahlert, Y., Westermann, F., Eils, R., Berthold, F., Shi, L., Wolfinger, R.D., Fischer, M., and Brors, B. (2010). Comparison of performance of one-color versus two-color gene-expression analyses in predicting clinical endpoints of neuroblastoma patients. Pharmacogenomics. 10: 258-266.
  • Tong, W., Shi, L., and Nikolsky, Y. (2010). Functional analysis of multiple genomic signatures demonstrates that classification algorithms choose phenotype-related genes. The Pharmacogenomics Journal. 10: 310-323.
  • Park, M., Rooney, A.P., Hecht, D., Li, J., Mcclane, B.A., Nayak, R.R., Paine, D.D., and Rafii, F. (2010). Phenotypic and genotypic characterization of tetracycline and minocycline resistance in Clostridium perfringens. Archives of Microbiology. 192(10): 803-10.
  • Parry, R., Jones, W.D., Stokes, T.H, Phan, J.H., Moffitt, R.A., Fang, H., Shi, L., Oberthuer, A., Fischer, M., Tong, W., and Wang, M.D. (2010). K-nearest neighbors models for microarray gene expression analysis and clinical outcome prediction. The Pharmacogenomics Journal. 10: 292-309.
  • Parsons, B.L. and Meng, F. (2009). K-RAS mutation in the screening, prognosis, and treatment of cancer. Biomarkers in Medicine. 3(6): 757-769.
  • Parsons, B.L., Marchant-Miros, K.E., Delongchamp, R.R., Verkler, T., Patterson, T.A., McKinzie, P.B., and Kim, L.T. (2010). Defining normal and pathological levels of tumor-associated mutations. Regulatory Research Perspectives. 9(1): 1-14.
  • Parsons, B.L., Myers, M.B., Meng, F., Wang, Y., and McKinzie, P.B. (2010). Oncomutations as biomarkers of cancer risk. Environmental and Molecular Mutagenesis. 51(8-9): 836-50.
  • Parsons, B.L., Verkler, T., Patterson, T.A., McKinzie, P.B., Marchant-Miros, K.E., Delongchamp, R.R., and Kim, L.T. (2010). ACB-PCR Quantification of K-RAS codon 12 GAT and GTT mutant fraction in colon tumor and non-tumor tissue: Insight into field cancerization. Cancer Investigation. 28: 364-365.
  • Patterson, T.A., Li, M., Hotchkiss, C.E., and Paule, M.G. (2010). Toxicity assessment of pramipexole in juvenile rhesus monkeys. Toxicology. 276(3): 164-171.
  • Patterson, T.A. and Paule, M.G. (2011). Cognitive assessments in nonhuman primates. Fundamental Neuropathology for Pathologists and Toxicologists: Principles and Techniques. Book chapter at publisher.
  • Patterson, T.A., Schnackenberg, B., Slikker, W., and Wang, C. (2011). Systems biology approaches to neurotoxicity studies during development. Developmental Neurotoxicology Research: Principles, Models, Techniques, Strategies and Mechanisms. Chapter 2: 25-38.
  • Paule, M.G. (2010). The nonhuman primate as a translational model for pesticide research. Hayes Handbook of Pesticide Toxicology 3rd Edition. Chapter 34: 847-859.
  • Paule, M.G. (2010). Behavioral approaches for assessing nervous system function during development in animal models. Developmental Neurotoxicology Research: Principles, Models, Techniques, Strategies and Mechanisms. Chapter 3: 39-52.
  • Paule, M.G. and Slikker, W. (2010). Developmental Neurotoxicity. Reproductive Toxicology 3rd Edition, Informational Healthcare.  157-167.
  • Piper, B.J., Ali, S.F., Daniels, L.G., and Meyer, J. (2010). Repeated intermittent methylenedioxymethamphetamine exposure protects against the behavioral and neurotoxic, but not hyperthermic, effects of an MDMA binge in adult rats. Synapse. 64(6): 421-431.
  • Pogribny, I.P., Filkowski, J., Tryndyak, V.P., Golubov, A., Shpyleva, S.I., and Kovalchuk, O. (2010). Alterations of microRNAs and their targets are associated with acquired resistance of MCF-7 breast cancer cells to cisplatin. International Journal of Cancer. 31: 1785-1794.
  • Pogribny, I.P., Muskhelishvili, L., Tryndyak, V.P., and Beland, F.A. (2010). The role of epigenetic events in genotoxic hepatocarcinogenesis induced by 2-acetylaminofluorene. Mutation Research. Feb 25, 2010: Epub ahead of print.
  • Pogribny, I.P., Starlard-Davenport, A., Tryndyak, V.P., Han, T., Ross, S., Rusyn, I., and Beland, F.A. (2010). Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice. Lab Investigation. 90(10): 1437-46.
  • Powell, C., Bradford, B., Craig, C., Tsuchiya, M., Uehara, T., O'Connell, T., Pogribny, I.P., Melnyk, S.B., Koop, D., Bleyle, L., Threadgill, D., and Rusyn, I. (2010). Mechanism for prevention of alcohol-induced liver injury by dietary methyl donors. Toxicology Science. 115(1): 131-139.
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