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FY 2008 Scientific Publications

  • Abdolpour, F., Shahverdi, A.R., Rafii, F., Fazeli, M., and Amini, M. 2007. Effects of piperitone on the antimicrobial activity of nitrofurantoin and on nitrofurantoin metabolism by Enterobacter cloacae. Pharmaceutical Biology. 45(3):230-234.
  • Ali, S.F. and Sharma, H.S. 2008. Acute Administration of 3,4-methylenedioxymethamphetamine induces profound hyperthermia, blood-brain barrier disruption, brain edema formation, and cell injury. Annals of the New York Academy of Sciences. 1139:242-258.
  • Antunes, A.M., Duarte, M.P., Santos, P.P., Gamboa Da Costa, G., Heinze, T.M., Beland, F.A. and Marques, M.M. 2008. Synthesis and characterization of DNA adducts from the HIV reverse transcriptase inhibitor nevirapine. Chemical Research in Toxicology. 21:1443-1456.
  • Arikawa, E., Sun, Y., Wang, J., Zhou, Q., Ning, B., Dial, S.L., Guo, L. and Yang, J. 2008. Cross-platform comparison of SYBR green real-time PCR with TaqMan PCR microarrays and other gene expression measurement technologies evaluated in the MAQC study. BMC Genomics. 9:328.
  • Arlt, V.M., Stiborova, M., Gamboa Da Costa, G., Farmer, P.B. and Phillips, D.H. 2008. Metabolic activation of benzo[a]pyrene in vitro by hepatic cytochrome P450 contrasts with detoxification in vivo: experiments with hepatic cytochrome P450 reductase null mice. Carcinogenesis. 29:656-65.
  • Axume, J. 2007. The MTHFR 677TT genotype and folate intake interact to lower global leukocyte DNA methylation in young Mexican American women. Nutrition Research. 27(1):1365-1317.
  • Baek, S., Moon, H., Ahn, H., Kodell, R.L., Lin, and Chen, J.J. 2008. Identifying high-dimensional biomarkers for personalized medicine via variable importance ranking. Journal of Biopharmaceutical Statistics. 18:1-16.
  • Bagnyukova, T.V., Tryndyak, V.P. and Pogribny, I.P. 2008. Induction of oxidative stress and DNA damage in rat brain by a folate/methyl-deficient diet. Brain Research. 1237:44-51.
  • Bagnyukova, T.V., Tryndyak, V.P., Montgomery, B.A., Churchwell, M.I., Karpf, A.R., Muskhelishvili, L., Beland, F.A. and Pogribny, I.P. 2008. Genetic and epigenetic changes in rat preneoplastic liver tissue induced by 2-acetylaminofluorene. Carcinogenesis. 29(3):638-46.
  • Bagnyukova, T.V., Tryndyak, V.P., Muskhelishvili, L., Ross, S., Beland, F.A. and Pogribny, I.P. 2008. Epigenetic downregulation of the suppressor of cytokine signaling 1 (Socs1) gene is associated with the STAT3 activation and development of hepatocellular carcinoma induced by methyl-deficiency in rats. Cell Cycle. 7(20):3202-3210.
  • Beger, R., Buzatu, D.A. and Wilkes, J.G. Quantitative Spectrometric Data-Activity Relationships (QSDAR) models of endocrine disruptor binding activities. CRC Press. (Book Chapter).
  • Beger, R., Holland, R.D., Sun, J., Schnackenberg, L., Devarajan, P., Dent, C. and Portilla, D. 2008. Metabolomics of acute kidney injury in children after cardiac surgery. Pediatric Nephrology. 23(6):977-984.
  • Boctor, S.Y., Wang, C. and Ferguson, S.A. 2008. Neonatal PCP or ketamine treatment modifies preweaning behaviors in Sprague-Dawley rats. Toxicological Sciences. 106(1):172-179.
  • Bowyer, J.F., Latendresse, J.R., Delongchamp, R.R., Muskhelishvili, L., Warbritton, A.R., Thomas, M., Tareke, E., McDaniel, L.P. and Doerge, D.R. 2008. The effects of subchronic acrylamide exposure on gene expression, neurochemistry, hormones, and histopathology in the hypothalamus-pituitary-thyroid axis of male Fischer 344 rats. Toxicology and Applied Pharmacology. 230(2):208-215.
  • Cederroth, C.R., Vinciguerra, M., Kuhne, F., Doerge, D.R., Foti, M., Rohner-Jeanrenaud, F., Vassalli, J. and Nef, S. 2008. Dietary phytoestrogens activate AMP-activated protein kinase with improvement in lipid and glucose metabolism. Diabetes. 57(5):1176-1185.
  • Cerniglia, C.E. and Sutherland, J.B. Degradation of polycyclic aromatic hydrocarbons by fungi. Microbiology of Hydrocarbons, Oils, Lipids, and Derived Compounds. In (T. McGenity) Springer-Verlag, Heidelberg. (Book Chapter).
  • Chan, P.C. and Fu, P.P. 2007. Toxicity of Panax genseng - An herbal medicine and dietary supplement. Journal of Food and Drug Analysis. 15:416-27.
  • Chang, C., Zou, W. and Chen, J.J. 2008, A new method for gene identification in comparative genomic analysis. Journal of Data Science. 6:415-427.
  • Chen, D., Chen, D., Schell, M.J., Chen, J.J., Fulp, W.J., Eschrich, S. and Yeatman, T. 2008. A predictive risk probability approach for microarray data with survival as the endpoint. Journal of Biopharmaceutical Statistics. 18(5):841-852.
  • Chen, H., Xu, H., Kweon, O., Chen, S. and Cerniglia, C.E. 2008. Functional role of the Trp-105 of an Enterococcus faecalis azoreductase (AzoA) as resolved by structural and mutational analysis. Microbiology. 154:2659-2667.
  • Chen, J.J., Chen, Y. and Cheng, K.F. 2007. Statistics for risk assessment of chemical carcinogens. Journal of Environmental Science and Health, Part C, Environmental Carcinogenesis and Ecotoxicology Reviews. 25:281-312.
  • Chen, J.J., Hsueh, H., Delongchamp, R.R., Lin, C.J. and Tsai, C. 2007. Reproducibility of microarray data: A further analysis of microarray quality control data. BMC Bioinformatics. 8:412.
  • Chen, T. 2007. Genotoxicity of aristolochic acid, a review. Journal of Food and Drug Analysis. 15(4):387-394. (Book Chapter).
  • Chen, T., Heflich, R.H., Moore, M. and Harris, A.J. 2008. Genetic toxicology. American Industrial Hygiene Association. 13:136-154. (Book Chapter).
  • Delongchamp, R.R., Velasco-gonzalez, C., Desai, V.G., Lee, T. and Fuscoe, J. 2008. Designing toxicogenomics studies that use DNA array technology. Bioinformatics and Biology Insights. 2:323-334.
  • Desai, V.G., Lee, T., Delongchamp, R.R., Leakey, J.E., Lewis, S.M., Lee, F.W., Moland, C.L., Branham, W.S. and Fuscoe, J. 2008. Nucleoside reverse transcriptase inhibitors (NRTIs) induced expression profile of mitochondrial genes in the mouse liver. Mitochondrion. 8:181-195.
  • Desai, V.G., Lee, T., Moland, C.L., Branham, W.S., Von Tungeln, L.S., Beland, F.A. and Fuscoe, J. 2008. Effect of short-term exposure to zidovudine (AZT) on the expression of mitochondria-related genes in skeletal muscle of neonatal mice. Mitochondrion. (1):9-16.
  • Doerge, D.R., Young, J.F., Chen, J.J., Dinovi, M. and Henry, S.H. 2008. Using diet exposure and physiologically based pharmacokinetic/pharmacodynamic modeling in human risk extrapolations for acrylamide toxicity. Journal of Agricultural and Food Chemistry. 56(15):6031-6038.
  • Duffy, P.H., Lewis, S.M., Mayhugh, M.A., Trotter, R.W., Thorn, B.T. and Feuers, R.J. 2008. Non-neoplastic pathology in male Sprague-Dawley rats fed the AIN-93M purified diet at ad libitum and dietary restricted intakes. Nutrition Research. 28(3):179-189.
  • Elkins, C., Munoz, M.E., Mullis, L. and Hart, M.E. 2008. Lactobacillu-mediated inhibition of clinical toxic syndrome Staphylococcus aureusstrains and its relation to acid and peroxide production. Anaerobe. 14(5):261-267.
  • Fan, X., Wang, Y., Perkins, R.G., Cheng, Y. and Tong, W. Feature fusion for chromatographic fingerprinting and its application to quality control of botanical drugs. European Journal of Pharmaceutics and Biopharmaceutics.
  • Fang, H., Harris, S.C., Su, Z., Chen, M., Qian, F., Shi, L., Perkins, R.G. and Tong, W. ArrayTrack-An FDA and public genomic tool. Methods of Functional Analysis (Pathways and Networks). The Humana Press, Inc., Totowa, NJ. (Book Chapter).
  • Fang, H., Perkins, R.G., Shi, L., Sheehan, D.M. and Tong, W. The FDA's Endocrine Disruptor Knowledge Base (EDKB)—lessons learned in QSAR modeling and applications. Devillers-Endocrine Disruption Modelling. Taylor & Francis Group, LLC, Boca Raton, FL. (Book Chapter).
  • Fang, J., McGarrity, L.J. and Beland, F.A. 2008. Interference of cell cycle progression by zidovudine and lamivudine in NIH 3T3 cells. Mutagenesis. 24(2):133-141.
  • Ferguson, S.A., Gopee, N., Paule, M.G. and Howard, P. 2009. Female mini-pig performance of temporal response differentiation, incremental repeated acquisition, and progressive ratio operant tasks. Behavioural Processes. 80(1):28-34.
  • Fu, P.P. 2007. Quality assurance and safety of herbal dietary supplements. Journal of Food and Drug Analysis. 15:333-334.
  • Fu, P.P., Xia, Q., Chou, M.W. and Lin, G. 2007. Detection, hepatotoxicity, and tumorigenicity of pyrrolizidine alkaloids in Chinese herbal plants and herbal dietary supplements. Journal of Food and Drug Analysis. 15:400-415.
  • Fu, P.P., Xia, Q., Guo, L., Yu, H. and Chan, P.C. 2008. Toxicity of kava kava. Journal of Environmental Health. Part C. Environmental Carcinogenogenesis and Ecotoxicology Reviews. 26(1):89-112.
  • Fuscoe, J. (2008). Impact of systems toxicology on the 3Rs. Alternatives to Animal Testing and Experimentation. 14:629-632.
  • Gamboa Da Costa, G., Phillips, D.H. and Arlt, V.M. 2008. Gene expression profiles modulated by the human carcinogen aristolochic acid l in human cancer cells and their dependence on TP53. Toxicology and Applied Pharmacology. 232:86-98.
  • Gerecke, D.R., Chen, M., Isukapalli, S., Chang, Y., Tong, W., Welsh, W.J., Androulakis, I.P. and Georgopoulos, P. 2009. Differential gene expression profiling of mouse skin after sulfur mustard exposure: extended time response and inhibitor effect. Toxicology and Applied Pharmacology. 234(2):156-165.
  • González-Cortés, C., Salinas-Lara, C., Gómez-López, M.A., Tena-Suck M.L., Pérez-De La Cruz, V., Rembao-Bojórquez, D., Pedraza-Chaverrí, J., Gómez-Ruiz, C., Galván-Arzate, S., Ali, S.F., and Santamaría, A. 2008. Iron porphyrinate FeTTPS reduces brain cell damage in intrastriatally rats lesioned by quinolinate. Journal of Neurochemistry. 30(6):510-519.
  • Hong, H., Su, Z., Ge, W., Shi, L., Perkins, R.G., Fang, H., Xu, Z., Chen, J.J., Han, T., Kaput, J., Fuscoe, J. and Tong, W. 2008. Assessing batch effects of genotype calling algorithm BRLMM for the Affymetrix GeneChip Human Mapping 500K array set using 270 HapMap samples. BMC Bioinformatics. 9(Suppl 9):S17.
  • Hong, H., Xie, Q., Ge, W., Qian, F., Fang, H., Shi, L., Su, Z., Perkins, R.G. and Tong, W. 2008. Mold2, molecular descriptors from 2D structures for chemoinformatics and toxicoinformatics. Journal of Chemical Information and Modeling. 48:1337-1344.
  • Hotchkiss, C.E., Bishop, M.E., Dertinger, S.D., Slikker, W., Moore, M. and MacGregor, J.T. 2008. Flow cytometric analysis of micronuclei in peripheral blood reticulocytes IV: An index of chromosomal damage in the rhesus monkey (Macaca mulatta). Toxicological Sciences. 102:352-358.
  • Jones, R.C., Deck, J., Edmondson, R.D. and Hart, M.E. 2008. Relative quantitative comparisons of the extracellular protein profiles of Staphylococcus aureus UAMS-1 and its sarA, agr, and sarA agr regulatory mutants using one-dimensional polyacrylamide gel electrophoresis and nanocapillary liquid chromatography coupled with tandem mass spectrometry. Journal of Bacteriology. 190(15):5265-5278.
  • Ju, Y.H., Doerge, D.R., Hartman, J.A., Kwak, J. and Helferich, W.G. 2008. Dietary genistein negates the inhibitory effect of letrozole on the growth if aromatase-expressing estrogen-dependent human breast cancer cells (MCF-7Ca) in vivo. Carcinogenesis. 29(11);2162-2168.
  • Jung, C.M., Heinze, T.M., Deck, J., Strakosha, R. and Sutherland, J.B. 2008. Transformation of N-phenylpiperazine by mixed cultures from a municipal wastewater treatment plant. Applied and Enviromental Microbiology. 74(19):6147-6150.
  • Jung, C.M., Heinze, T.M., Strakosha, R., Elkins, C. and Sutherland, J.B. 2009. Acetylation of fluoroquinolone antimicrobial agents by an Escherichia coli strain isolated from a municipal wastewater treatment plant. Journal of Applied Microbiology. 106:564:571.
  • Kaldhone, P., Nayak, R.R., Lynne, A.M., Mcdermott, P.F., Logue, C.M., Foley, S.L. and David, D.E. 2008. Characterization of Salmonella enterica serovar Heidelberg from turkey-associated sources. Applied and Environmental Microbiology. 74(16):5038-5046.
  • Kaput, J. 2008. Nutrigenomics research for personalized nutrition and medicine. Current Opinions in Biotechnology. 19:110-120.
  • Kim, S., Kweon, O. and Cerniglia, C.E. Degradation of polycyclic aromatic hydrocarbons by Mycobacterium strains. Springer Science and Business Media. In (Kenneth N. Timmis) Springer Science and Business Media, Heidelberg, Germany. (Book Chapter).
  • Kim, S., Kweon, O., Jones, R.C., Edmondson, R.D. and Cerniglia, C.E. 2008. Genomic analysis of polycyclic aromatic hydrocarbon degradation in Mycobacterium vanbaalenii PYR-1, Biodegradation. 19:859-881.
  • Kim, Y., and Cerniglia, C.E. An overview of the fate and effects of antimicrobials used in aquaculture. Veterinary Pharmaceuticals in the Environment. In (K. Henderson and J. Coats) American Chemical Society. (Book Chapter).
  • Kovalchuk, O., Tryndyak, V.P., Chekhun, V.F. and Pogribny, I.P. 2008. Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin. Molecular Cancer Therapeutics. 7(7):2152-2159.
  • Kweon, O., Kim, S. and Cerniglia, C.E. Genomic view of mycobacterial high-molecular-weight polycyclic aromatic hydrocarbon degradation. Handbood of Hydrocarbon Microbiology. Book Chapter).
  • Kweon, O., Kim, S., Baek, S., Adjei, M.D. and Cerniglia, C.E. 2008. A new classification system for bacterial Rieske non-heme iron aromatic ring-hydroxylating oxygenases. BMC Biochemistry. 9:11.
  • Lee, T., Desai, V.G., Velasco-gonzalez, C. and Delongchamp, R.R. 2008. Testing for treatment effects on gene ontology. BMC Bioinformatics. 9:S20.
  • Li, S., Lin, G., Fu, P.P., Chan, C., Jiang, Z. and Zhao, Z. 2008. Identification of five hepatotoxic pyrrolizidine alkaloids in a commonly used traditional Chinese medicinal herb. Herba Senecionis scandentis(Qianliguang). Rapid Communication in Mass Spectrometry. 22(4):591-602.
  • Luecke, R., Pearce, B.A., Wosilait, W.D., Doerge, D.R., Slikker, W. and Young, J.F. 2008. Windows-based general PBPK/PD modeling software. Computers in Biology and Medicine. 38:962-978.
  • Malejka-Giganti, D., Parkin, D.R., Decker, R.W., Niehans, G.A., Bliss, R., Churchwell, M.I. and Beland, F.A. 2008. Tumorigenicity and genotoxicity of an environmental pollutant 2,7-dinitrofluorene after systemic administration at a low dose level to female rats. International Journal of Cancer. 122(9):1958-1965.
  • Manjanatha, M., Shelton, S.D., Dobrovolsky, V.N., Shaddock, J.G., McGarrity, L.J., Doerge, D.R., Twaddle, N.C., Lin, Chien-Ju, Chen, J.J., Mattison, D. and Morris, S.M. 2008. Pharmacokinetics, dose-range, and mutagenicity studies of methylphenidate hydrochloride in B6C3F1 mice. Environmental and Molecular Mutagenesis. 49(8):585-593.
  • Mckinney, M.D., Moon, S., Kulesh, D.A., Larsen, T. and Schoepp, R.J. 2009. Detection of viral RNA from parraffin-embedded tissues after prolonged formalin fixation. Journal of Clinical Virology. 44:39-42.
  • Mei, N., Manjanatha, M., Azuma, M., McDaniel, L.P., Dial, S.L., Tseng, J., Liao, W. and Guo, L. 2008. Liver gene expression profile of mice treated with acrylamide in drinking water. Proceedings of the 2008 International Conference on Bioinformatics and Computational Biology. I:131-137.
  • Mei, N., Guo, L., Tseng, J., Dial, S.L., Liao, W. and Manjanatha, M. 2008. Gene expression changes associated with xenobiotic metabolism pathways in mice exposed to acrylamide. Environmental Health and Molecular Mutagenesis. 49(9):741-745.
  • Mendoza, M., Burns, T.L. and Jones, M.P. 2009. Case-deletion diagnostics for maximum-likelihood multipoint quantitative-trait locus linkage analysis. Human Heredity. 67(4):276-286.
  • Miura, D., Dobrovolsky, V.N., Kasahara, Y., Katsuura, Y. and Heflich, R.H. 2008. Development of an in vivo gene mutation assay using the endogenous PIG-A gene: I. Flow cytometric detection of CD59-negative peripheral red blood cells and CD48-negative spleen T-cells from the rat. Environmental and Molecular Mutagenesis. 49:614-621.
  • Miura, D., Dobrovolsky, V.N., Mittelstaedt, R.A., Kasahara, Y., Katsuura, Y. and Heflich, R.H. 2008. Development of an in vivo gene mutation assay using the endogenous PIG-A gene: II. Selection of PIG-A mutant rat spleen T-cells with proaerolysin and sequencing PIG-A cDNA from the mutants. Environmental and Molecular Mutagenesis. 49:622-630.
  • Moore, M., Heflich, R.H., Allen, B.C., Shipp, A.M., Kodell, R.L. and Haber, L. 2008. Analysis of in vivo mutation data can inform cancer risk assessment. Regulatory Toxicology and Pharmacology. 51:151-161.
  • Morris, S.M., Akerman, G.S., Desai, V.G., Tsai, C., Tolleson, W.H., Melchior, W.B., Lin, C., Fuscoe, J., Casciano, D.A. and Chen, J.J. 2008. Effect of p53 genotype on gene expression profiles in murine liver. Mutation Research. 640(1-2):54-73.
  • Nayak, R.R. and Stewart, T.M. 2008. Molecular epidemiological analysis and microbial source tracking of Salmonella enterica serovars in a preharvest turkey production environment. Foodborne Pathogens and Disease. 5, No. 2:115-126.
  • Ning, B., Dial, S.L., Sun, Y., Wang, J., Yang, J. and Guo, L. 2008. Systematic and simultaneous gene profiling of 84 drug metabolizing genes in primary human hepatocytes. Journal of Biomolecular Screening. 13(3):194-201.
  • Parsons, B.L. 2008. Many different tumor types have polyclonal origin: evidence and implications. Mutation Research: Reviews in Mutation Research. 659:232-247.
  • Parsons, B.L., Verkler, T., Delongchamp, R.R., Couch, L.H., Miller, B.J., Warbritton, A.R., Mellick, P.W. and Howard, P. 2008. Populations of p53 colon 270 CGT to TGT mutant cells in SKH-1 mouse skin tumors induced by simulated solar light. Molecular Carcinogenesis. 47(11):822-834.
  • Paule, M.G. 2008. Exposure to drugs of abuse: alterations in nonhuman primate development as models of adverse consequences. Nonhuman Primate Models of Children's Health and Developmental Disabilities. 301-324. (Book Chapter).
  • Pérez-De La Cruz, V., Konigsberg, M., Pedraza-Chaverri, J., Herrera-Mundo, N., Díaz-Muñoz, M., Morán, J., Fortoul-van der Goes, T., Rondán-Zárate, A., Maldonado, P.D., Ali, S.F. and Santamaría, A. 2008. Cytoplasmic calcium mediates oxidative damage in an excitotoxic /energetic deficit synergic model in rats. European Journal of Neuroscience. 27(5):1075-1085.
  • Petibone, D.M., Morris, S.M., Hotchkiss, C.E., Mattison, D. and Tucker, J.D. 2008. Technique for culturing Macaca mulatta peripheral blood lymphocytes for fluorescence in situ hybridizaiton of whole chromosome paints. Mutation Research. 653:76-81.
  • Pogribna, M.V., Freeman, J.P., Paine, D.D. and Boudreau, M.D. 2008. Effect of Aloe vera whole leaf extract on short chain fatty acids production by Bacteroides fragilis. Bifidobacterium infantisand Eubacterium limosum. Letters in Applied Microbiology. 46(5):575-580.
  • Pogribny, I.P., Karpf, A.R., James, S.R., Melnyk, S.B., Han, T. and Tryndyak, V.P. 2008. Epigenetic alterations in the brains of Fisher 344 rats induced by long-term administration of folate/methyl-deficient diet. Brain Research. 1237:25-34.
  • Pogribny, I.P., Tryndyak, V.P., Boureiko, A.Y., Melnyk, S.B., Bagnyukova, T.V., Montgomery, B.A. and Rusyn, I. 2008. Mechanisms of peroxisome proliferator-induced DNA hypomethylation in rat liver. Mutation Research. 644(1-2):17-23.
  • Pogribny, I.P., Tryndyak, V.P., Ross, S. and Beland, F.A. 2008. Differential expression of microRNAs during hepatocarcinogenesis induced by methyl deficiency in rats. Nutrition Reviews. Suppl 66(1):S33-35.
  • Porola, P., Virkki, L., Przybyla, B.D., Laine, M., Patterson, T.A., Pihakari, A. and Konttinen, Y.T. 2008. Androgen deficiency and defective intracrine processing of DHEA in the salivary glands in Sjögren’s syndrome. Journal of Rheumatology. 35:2229-2235.
  • Rafii, F., and Park, M. 2008. Detection and characterization of an ABC transporter in Clostridium hathewayi. Archives of Microbiology. 190:417-426.
  • Rafii, F., Park, M., Bryant, A.E., Johnson, S.J. and Wagner, R.D. 2008. Enhanced production of phospholipase C and perfringolysin O (alpha and theta toxins) in a gatifloxacin-resistant strain of Clostridium perfringens. Antimicrobial Agents and Chemotherapy. 52, No. 3:895-900.
  • Reynisson, J., Stiborova, M., Martinek, V., Gamboa Da Costa, G., Phillips, D.H. and Arlt, V.M. 2008. Mutagenic potential of nitrenium ions of nitrobenzanthrones: correlation between theory and experiment. Environmental and Molecular Mutagenesis. 49:659-667.
  • Sanchez-Diaz, A., Marchesis, V., Murray, S., Jones, R.C., Pereira, G., Edmondson, R.D., Allen, T. and Labib, K. 2008. Inn1 couples contraction of the actomyosin ring to membrane ingression during cytokinesis in budding yeast. Nature Cell Biology. 10(4):395-406.
  • Sansone, S.A., Rocca-Serra, P., Brandizi, M., Brazma, A., Field, D., Fostel, J., Garrow, A.G., Gilbert, J., Goodsaid, F., Hardy, N., Jones, P., Lister, A., Miller, M., Morrison, N., Rayner, T., Sklyar, N., Taylor, C., Tong, W., Warner, G., and Wiemann, S. 2008. The first RSBI (ISA-TAB) workshop: "can a simple format work for complex studies?" OMICS: A Journal of Integrative Biology. 12(2):143-149.
  • Schnackenberg, L., and Beger, R. 2007. Metabolomics biomarkers: their role in the Critical Path. Drug Discovery Today: Technologies. 4(1):13-16.
  • Schnackenberg, L., Kaput, J. and Beger, R. 2008. Metabolomics: a tool for personalizing medicine? Personalized Medicine. 5(5):495-504.
  • Shi, L., Jones, W.D., Jensen, R.V., Harris, S.C., Perkins, R.G., Goodsaid, F.M., Guo, L., Croner, L.J., Boysen, C., Fang, H., Amur, S., Bao, W., Barbacioru, C.C., Bertholet, V., Cao, X., Chu, T., Collins, J., Fan, X., Frueh, F.W., Fuscoe, J., Guo, X., Han, J., Herman, D., Hong, H., Kawasaki, E.S., Li. Q., Luo, Y., Ma, Y., Mei, N., Peterson, R., Puri, R.K., Qian, F., Shippy, R., Su, Z., Sun, Y., Sun, H., Thorn, B.T., Turpaz, Y., Wang, C., Wang, S., Warrington, J.A., Willey, J.C., Wu, J., Zie, Q., Zhang, L., Shong, S., Chen, J.J., Wolfinger, R.D., and Tong, W. 2008. The balance of reproducibility, sensitivity, and specificity of lists of differentially expressed genes in microarray studies. BMC Bioinformatics. 9(Suppl 9):S10.
  • Shi, L., Perkins, R.G., Fang, H. and Tong, W. 2008. Reproducible and reliable microarray results through quality control: good laboratory proficiency and appropriate data analysis practices. Current Opinion in Biotechnology. 19:10-18.
  • Silva-Adaya, D., Pérez-De La Cruz, V., Herrera-Mundo, M.N., Mendoza-Macedo, K., Villeda-Hernández, J., Binienda, Z., Ali, S.F., and Santamaría, A. 2008. Excitotoxic damage, disrupted energy metabolism, and oxidative stress in the rat brain: antioxidant and neuroprotective effects of L-carnitine. Journal of Neurochemistry. 105(3):677-89.
  • Slikker, W., Mattison, D., Shelby, M. and Tice, R. Letter to Cancer Letters re: Methylphenidate. Cancer Letters.
  • Starlard-Davenport, A. and Lyn-Cook, B.A. 2008. Identification of UDP-glucuronosyltransferase 1A10 in non-malignant and malignant human breast tissues. Steroids. 73(6):611-621.
  • Su, Z., Hong, H., Fang, H., Shi, L., Perkins, R.G. and Tong, W. 2008. Very Important Pool (VIP) genes — an application for microarray-based molecular signatures, BMC Bioinformatics. 9(Supp 9):S17.
  • Sun, J., Schnackenberg, L., Holland, R.D., Schmitt, T.C., Reily, M.D., Robertson, D.G., Cantor, G.H., Dragan, Y. and Beger, R. 2008. Metabonomics evaluation of urine from rats given acute and chronic doses of acetaminophen using NMR and UPLC/MS. Journal Chromatography B. 871:328-340.
  • Sung, K., Khan, S.A. and Nawaz, M.S. 2008. Genetic diversity of Tn1546-like elements in clinical isolates of vancomycin-resistant enterococci. International Journal of Antimicrobial Agents. 31:549-554.
  • Sutherland, J.B., Heinze, T.M., Pearce, M.G., Deck, J., Williams, A.J. and Freeman, J.P. 2009. Biotransformation of acridine by Mycobacterium vanbaalenii. Environmental Toxicology and Chemistry. 28(1):61-64.
  • Tamminga, J., Koturbash, I., Baker, M., Kutanzi, K., Kathiria, P., Pogribny, I.P. and Kovalchuk, O. 2008. Paternal cranial irradiation induces distant bystander DNA damage in the germline and leads to epigenetic alterations in the offspring. Cell Cycle. 7(9):1238-1245.
  • Tareke, E., Bowyer, J.F. and Doerge, D.R. 2007. Quantification of rat brain neurotransmitters and metabolites using liquid chromatography/electrospray tandem mass spectrometry and comparison with liquid chromatography/electrochemical detection. Journal of Chromatography B. 21(23):3898-3904.
  • Tareke, E., Lyn-Cook, B.A., Robinson, B.L. and Ali, S.F. 2008. Acrylamide: a dietary carcinogen formed in vivo? Journal of Agriculture and Food Chemistry. 56(15):6020-6023.
  • Tong, W., Harris, S.C., Fang, H., Shi, L., Perkins, R.G., Goodsaid, F.M. and Frueh, F.W. 2007. An integrated bioinformatics infrastructure essential for advancing pharmacogenomics and personalized medicine in the context of the FDA's Critical Path Initiative. Drug Discovery Today. 4(1):3-8.
  • Valentine, C.R., Rainey, H.F., Farrell, J.M., Shaddock, J.G., Dobrovolsky, V.N. and Delongchamp, R.R. 2008. Frequency and spectrum of ENU-induced mutation in the Phi X174 transgene in mouse splenic lymphocytes and their significance to spontaneous transgenic rodent mutation frequencies. Mutagenesis. 1-15.
  • Verkler, T., Delongchamp, R.R., Couch, L.H., Miller, B.J., Mellick, P.W., Warbritton, A.R., Howard, P. and Parsons, B.L. 2008. Populations of p53 codon 270 CGT to TGT mutant cells in SKH-1 mouse skin tumors induced by simulated solar light. Molecular Carcinogenesis. 47:822-834.
  • Verkler, T., Delongchamp, R.R., Miller, B.J., Webb, P., Howard, P. and Parsons, B.L. 2008. Simulated solar light-induced p53 mutagenesis in SKH-1 mouse skin: a dose-response assessment. Molecular Carinogenesis. 47(8):599-607.
  • Wagner, R.D., Johnson, S.J. and Cerniglia, C.E. 2008. In vitro model of colonization resistance by the enteric microbiota: effects of antimicrobial agents used in food-producing animals. Antimicrobial Agents and Chemotherapy. 52:4:1230-1237.
  • Wagner, R.D., Johnson, S.J. and Rubin, D.K. 2009. Probiotic bacteria are antagonistic to Salmonella enterica and Campylobacter jejuni and influence host lymphocyte responses in human microbiota-associated immunodeficient and immunocompetent mice. Molecular Food Nutrition Research. 53(3):377-88.
  • Wagner, R.D., Rubin, D.K. and Johnson, S.J. 2008. Vancomycin-resistant Lactococcus lactis 1A-1 isolated from a competitive exclusion product transfers vancomycin resistance genes to Staphylococcus aureus. Open Food Science Journal. 2:72-76.
  • Wang, C., Sadovova, N.V., Patterson, T.A., Zou, X., Fu, X., Hanig, J.P., Paule, M.G., Ali, S.F., Slikker, W. and Zhang, X. 2008. Protective effects of 7-nitroindazole on ketamine-induced neurotoxicity in rat forebrain culture. Neurotoxicology. 29(4):613-620.
  • Wang, J.C., Duhart, H.M., Xu, Z., Patterson, T.A., Newport, G.D. and Ali, S.F. 2008. Comparison of the time-courses of selective gene expression and dopaminergic depletion induced by MPP+ in MN9D cells. Neurochemistry International. 52:1037-1043.
  • Wang, X., Tryndyak, V.P., Pogribny, I.P. and Basnakian, A.G. 2008. Sensitivity of human prostate cancer cells to chemotherapeutic drugs depends on EndoG expression regulated by promoter methylation. Cancer Letters. 270(1):132-143.
  • Wilkes, J.G., Hass, B.S., Buzatu, D.A., Pence, L.M., Archer, J., Beger, R., Schnackenberg, L., Halbert, M.K., Jennings, L. and Kodell, R.L. 2008. Modeling and assaying dioxin-like biological effects for both dioxin-like and certain non-dioxin-like compounds. Toxicological Sciences. 102:187-195.
  • Wong, T., Chang, L., Lee, F., Wang, X. and Fu, P.P. 2007. A survey of heavy metals and organochlorine pesticides contaminations in commercial Ling Zhi products. Journal of Food and Drug Analysis. 15:472-79.
  • Wren, J.D., Wilkins, D., Fuscoe, J., Bridges, S., Winters-Hilt, S. and Gusev, Y. 2008. Proceeding of the 2008 MidSouth Computational Biology and Bioinformatics Society (MCBIOS) Conference. BMC Bioinformatics. 9(Suppl 9):S1.
  • Wright, L.K., Paule, M.G., Pearson, E. and Hammond, T. 2007. Behavioral effects associated with chronic ketamine or remacemide exposure in rats. Neurotoxicology and Teratology. 29:348-359.
  • Xia, Q., Yan, J., Chou, M.W. and Fu, P.P. 2008. Formation of DHP-derived DNA adducts from metabolic activation of heliotrine. Toxicology Letters. 178(2):77-82.
  • Xu, H., Heinze, T.M., Chen, S., Cerniglia, C.E. and Chen, H. 2007. Anaerobic metabolism of 1-Amino-2-Naphthol-Based azo dyes (Sudan dyes) by human intestinal microflora. Applied and Environmental Microbiology. 73(23):7759-7762.
  • Yan, J., Xia, Q., Wamer, W., Boudreau, M.D., Warbritton, A.R., Howard, P. and Fu, P.P. 2007. Levels of retinyl palmitate and retinol in the skin of SKH-1 mice topically treated with retinyl palmitate and concomitant exposure to simulated solar light for thirteen weeks. Toxicology and Industrial Health. 23(10):581-589.
  • Yauk, C., Polyzos, A., Rowan-Carroll, A., Somers, C.M., Godschalk, R.W., Van Schooten, F., Berndt, M., Pogribny, I.P., Koturbash, I., Williams, A., Douglas, G.W. and Kovalchuk, O. 2008. Germline mutations, DNA damage and global hypermethylation in mice exposed to particulate air pollution in an urban/industrial location. Proceeding of the National Academy of Sciences of the United States of America. 105(2):605-10.
  • Yin, J., Fu, P.P. and Liang, X. 2008. Superior capability of eliminating free radicals by polyhydroxylated endohedral metallofullerenol optimized as reactive oxygen species scavenger. Molecular Pharmacology. 74:1132-1140.
  • Zhang, J., Dhakal, I., Ning, B., and Kesteloot, H. 2008. Patterns and trends of pancreatic cancer mortality rates in Arkansas, 1969-2002: a comparison with the US population. European Journal of Cancer Prevention. 17(1):18-27.
  • Zhang, X., Patterson, T.A., Paule, M.G., Slikker, W. and Wang, C. The role of NMDA glutamate receptors in pain and anesthetic-induced neurodegeneration during development. Amino Acid Receptor Research. Nova Science Publishers, Inc, Hauppauge, New York. (Book Chapter).
  • Zou, X., Sadovova, N.V., Patterson, T.A., Divine, B.L., Hotchkiss, C.E., Ali, S.F., Hanig, J.P., Paule, M.G., Slikker, W. and Wang, C. 2008. The effects of L-carnitine on the combination of inhalation anesthetic-induced developmental neuronal apoptosis in the rat frontal cortex. Neuroscience. 151(4):1053-1065.

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