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NCTR Research Highlights

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Current Highlight from August 21, 2015

Fructose Metabolism in Human Adiopcytes

Scientists from NCTR, Harbor-UCLA Medical Center, University of Ulm (Germany), and Nestle Institute of Health Sciences (Switzerland) have shown that fructose stimulates anabolic processesin adipocytes (fat cells) including 1) increased glutamate and fatty acid synthesis and 2) increased fatty acid release from adipocytes. To study the metabolic responses to fructose, targeted stable isotope methods were used in cultured human fat cells that were exposed to a range of fructose concentrations equivalent to that reported in blood after consuming fructose. Additional in vivo studies are warranted as these results suggest that fatty acid accumulation is a key consequence of fructose metabolism in adipocytes. This study is available online at Metabolomicsdisclaimer icon.

For more information, contact Vijayalakshmi Varma, Biomarkers and Alternative Models Branch, Division of Systems Biology, or Richard Beger, Director, Biomarkers and Alternative Models Branch, Division of Systems Biology, FDA/NCTR.


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Page Last Updated: 09/02/2015
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