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NCTR Research Highlights

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Current Highlight from December 5, 2014

Biomarkers of Tobacco Smoke Exposure

NCTR scientists, in collaboration with colleagues from FDA's Center for Tobacco Products recently published an extensive review of biomarkers that have been used to monitor exposure to and damage from tobacco smoke. This review, in the current edition of Advances in Clinical Chemistry (Volume 67)disclaimer icon examines both well accepted biomarkers such as urinary cotinine as well as more emerging biomarkers, such as genomic markers found in airway tissue. The review explores the range of biological matrices (urine, blood, saliva, sputum, exhalant, hair, toenails, and airway and nasal tissue) that can be used for biomarker measurements and contrasts biomarkers of exposure with those that measure biological dose or potential harm. The review explores the possible uses of such biomarkers, and the considerations for assay validation and biomarker qualification.

For additional information, please contact William Mattes, Ph.D., Director, Division of Systems Biology, FDA/NCTR.


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Page Last Updated: 12/09/2014
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